FB2026_03 , released September 17, 2026
CV Term Report
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Term methyltransferase activity ID (Ontology) GO:0008168 (Gene Ontology)
Definition Catalysis of the transfer of a methyl group to an acceptor molecule.[ ISBN:0198506732 ]
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 methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | methyltransferase activity       --
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  transferase activity
   |__transferase activity, transferring one-carbon groups
       |__methyltransferase activity  151 rec.
           |__(R,S)-reticuline 7-O-methyltransferase activity
           |__2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity
           |__2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity
           |__2-polyprenyl-6-hydroxyphenol methylase activity
           |__3',4',5'-trimethylmyricetin 3-O-methyltransferase activity
           |__3',4',5'-trimethylmyricetin 7-O-methyltransferase activity
           |__3-aminomethylindole N-methyltransferase activity
           |__3-methylquercetin 3'-O-methyltransferase activity
           |__4-hydroxytryptamine 4-phosphate methyltransferase activity
           |__5,10-methylenetetrahydrofolate-dependent methyltransferase activity 1 rec.
           |   |__thymidylate synthase (FAD) activity
           |   |__thymidylate synthase activity 1 rec.
           |__5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity
           |   |__tetrahydromethanopterin S-methyltransferase activity
           |__5-methyl-phenazine-1-carboxylate N-methyltransferase activity
           |__5-n-alk(en)ylresorcinol O-methyltransferase activity
           |__6-carboxymethyl-5-methyl-4-hydroxypyridin-2-ol 3-C-methyltransferase activity
           |__6a-hydroxymaackiain-3-O-methyltransferase activity
           |__8-demethylnovobiocic acid C8-methyltransferase activity
           |__[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase activity
           |__[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase activity
           |__apigenin 7-O-methyltransferase activity
           |__C-methyltransferase activity 6 rec.
           |   |__2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity 1 rec.
           |   |__2-phytyl-1,4-naphthoquinone methyltransferase activity
           |   |__deoxycytidylate C-methyltransferase activity
           |   |__protein-arginine C-methyltransferase activity
           |   |__rRNA (adenine(2503)-C2-)-methyltransferase activity
           |   |__rRNA (cytosine-C5-)-methyltransferase activity 5 rec.
           |   |__rRNA (uridine-C5-)-methyltransferase activity
           |   |__sterol 24-C-methyltransferase activity
           |   |__tRNA (adenine(37)-C2)-methyltransferase activity
           |   |__uroporphyrin-III C-methyltransferase activity
           |__caffeine synthase activity
           |__cirsimaritin 4'-O-methyltransferase activity
           |__cobalt-factor II C20-methyltransferase activity
           |__cobalt-precorrin-3 C17-methyltransferase activity
           |__cobalt-precorrin-5B C1-methyltransferase activity
           |__cobalt-precorrin-6B C5-methyltransferase activity
           |__cobalt-precorrin-7 C15-methyltransferase activity
           |__corydaline synthase activity
           |__daphnetin-8-O-methyltransferase activity
           |__demethylmenaquinone methyltransferase activity
           |__demethylrebeccamycin--D-glucose O-methyltransferase activity
           |__dimethyl selenide methyltransferase activity
           |__dimethylamine methyltransferase activity
           |__DNA-methyltransferase activity 1 rec.
           |   |__DNA (cytosine-5-)-methyltransferase activity(+) 1 rec.
           |   |__site-specific DNA-methyltransferase (adenine-specific) activity
           |   |__site-specific DNA-methyltransferase (cytosine-N4-specific) activity
           |__eriodictyol 3'-O-methyltransferase activity
           |__erythromycin 3''-o-methyltransferase activity
           |__flavanone 4'-O-methyltransferase activity
           |__genkwanin 4'-O-methyltransferase activity
           |__gibberellin A4 carboxyl methyltransferase activity
           |__gibberellin A9 carboxyl methyltransferase activity
           |__hydrogen selenide methyltransferase activity
           |__hydroxyneurosporene-O-methyltransferase activity
           |__indole acetic acid carboxyl methyltransferase activity
           |__indole-3-acetate carboxyl methyltransferase activity
           |__isorhamnetin 3-O-methyltransferase activity
           |__kaempferide 3-O-methyltransferase activity
           |__kaempferide 7-O-methyltransferase activity
           |__kaempferol 3-O-methyltransferase activity
           |__ladanein 6-O-methyltransferase activity
           |__malonyl-CoA methyltransferase activity
           |__methaneselenol methyltransferase activity
           |__methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity
           |__methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity
           |__methylthiol:coenzyme M methyltransferase activity
           |__monomethylamine methyltransferase activity
           |__mycinamicin VI 2''-O-methyltransferase activity
           |__myricetin 7-O-methyltransferase activity
           |__N-methyltransferase activity 82 rec.
           |   |__arginine N-methyltransferase activity(+) 13 rec.
           |   |__dimethylglycine N-methyltransferase activity
           |   |__glycine N-methyltransferase activity 1 rec.
           |   |__histamine N-methyltransferase activity
           |   |__lysine N-methyltransferase activity(+) 52 rec.
           |   |__methylamine-glutamate N-methyltransferase activity
           |   |__mRNA 5'-cap (guanine-N7-)-methyltransferase activity 1 rec.
           |   |__nicotinamide N-methyltransferase activity
           |   |__nicotinate N-methyltransferase activity
           |   |__phenylethanolamine N-methyltransferase activity
           |   |__phosphatidyl-N-methylethanolamine N-methyltransferase activity
           |   |__phosphatidylethanolamine N-methyltransferase activity
           |   |__phosphoethanolamine N-methyltransferase activity
           |   |__protein-glutamine N-methyltransferase activity(+) 5 rec.
           |   |__protein-L-histidine N-pros-methyltransferase activity 1 rec.
           |   |__protein-L-histidine N-tele-methyltransferase activity 2 rec.
           |   |__rRNA (adenine-N6,N6-)-dimethyltransferase activity(+) 3 rec.
           |   |__rRNA (adenine-N6-)-methyltransferase activity(+) 2 rec.
           |   |__rRNA (cytosine-N4-)-methyltransferase activity 1 rec.
           |   |__rRNA (guanine-N1-)-methyltransferase activity(+)
           |   |__rRNA (guanine-N2-)-methyltransferase activity(+)
           |   |__rRNA (guanine-N7-)-methyltransferase activity
           |   |__rRNA (uridine-N3-)-methyltransferase activity 1 rec.
           |   |__sarcosine N-methyltransferase activity
           |   |__trimethylsulfonium-tetrahydrofolate N-methyltransferase activity
           |   |__tRNA (guanine(6)-N2)-methyltransferase activity
           |   |__tRNA (guanine(7)-N2)-methyltransferase activity
           |   |__tRNA (guanine(10)-N2)-dimethyltransferase activity
           |   |__tRNA (guanine(10)-N2)-methyltransferase activity 1 rec.
           |   |__tRNA (guanine(26)-N2)-dimethyltransferase activity 1 rec.
           |   |__tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity
           |   |__tRNA (guanine(27)-N2)-dimethyltransferase activity
           |   |__tRNA(Val) (adenine(37)-N6)-methyltransferase activity
           |__naringenin 7-O-methyltransferase activity
           |__O-methyltransferase activity 15 rec.
           |   |__(iso)eugenol O-methyltransferase activity
           |   |__2-phytyl-1,4-naphthoquinone methyltransferase activity
           |   |__2-polyprenyl-6-hydroxyphenol O-methyltransferase activity
           |   |__3-demethylubiquinol 3-O-methyltransferase activity 1 rec.
           |   |__3-demethylubiquinone 3-O-methyltransferase activity
           |   |__4-vinylphenol methyltransferase activity
           |   |__acetylserotonin O-methyltransferase activity
           |   |__caffeate O-methyltransferase activity
           |   |__caffeoyl-CoA O-methyltransferase activity
           |   |__carboxyl-O-methyltransferase activity(+) 4 rec.
           |   |__catechol O-methyltransferase activity
           |   |__demethylsterigmatocystin 6-O-methyltransferase activity
           |   |__farnesoic acid O-methyltransferase activity 1 rec.
           |   |__flavone 3'-O-methyltransferase activity
           |   |__isoflavone 7-O-methyltransferase activity
           |   |__isoliquiritigenin 2'-O-methyltransferase activity
           |   |__kaempferol 4'-O-methyltransferase activity
           |   |__laricitrin 5'-O-methyltransferase activity
           |   |__magnesium protoporphyrin IX methyltransferase activity
           |   |__methyltransferase cap1 activity 2 rec.
           |   |__methyltransferase cap2 activity 1 rec.
           |   |__myricetin 3'-O-methyltransferase activity
           |   |__RNA 2'-O-methyltransferase activity(+) 4 rec.
           |   |__RNA 5'-gamma-phosphate methyltransferase activity
           |   |__S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity
           |   |__sterigmatocystin 7-O-methyltransferase activity
           |   |__tocopherol C-methyltransferase activity
           |   |__tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
           |   |__trihydroxyferuloyl spermidine O-methyltransferase activity
           |   |__trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
           |   |__vitexin 2''-O-rhamnoside 7-O-methyltransferase activity
           |__precorrin-6A synthase (deacetylating) activity
           |__protein methyltransferase activity 80 rec.
           |   |__diphthine methyl ester synthase activity 1 rec.
           |   |__diphthine synthase activity
           |   |__histone methyltransferase activity(+) 44 rec.
           |   |__methylated-DNA-[protein]-cysteine S-methyltransferase activity 1 rec.
           |   |__N-terminal protein N-methyltransferase activity 1 rec.
           |   |__protein carboxyl O-methyltransferase activity(+) 4 rec.
           |   |__protein-arginine C-methyltransferase activity
           |   |__protein-arginine N-methyltransferase activity(+) 13 rec.
           |   |__protein-cysteine methyltransferase activity 1 rec.
           |   |__protein-glutamine N-methyltransferase activity(+) 5 rec.
           |   |__protein-L-histidine N-pros-methyltransferase activity 1 rec.
           |   |__protein-L-histidine N-tele-methyltransferase activity 2 rec.
           |   |__protein-lysine N-methyltransferase activity(+) 52 rec.
           |__quercetin 7-O-methyltransferase activity
           |__resveratrol 3,5-O-dimethyltransferase activity
           |__rhamnetin 3'-O-methyltransferase activity
           |__rhamnetin 3-O-methyltransferase activity
           |__rhamnetin 4'-O-methyltransferase activity
           |__RNA methyltransferase activity 57 rec.
           |   |__methyltransferase cap1 activity 2 rec.
           |   |__methyltransferase cap2 activity 1 rec.
           |   |__mRNA methyltransferase activity(+) 6 rec.
           |   |__RNA 2'-O-methyltransferase activity(+) 4 rec.
           |   |__RNA 5'-gamma-phosphate methyltransferase activity
           |   |__RNA cap trimethylguanosine synthase activity 1 rec.
           |   |__rRNA methyltransferase activity(+) 21 rec.
           |   |__snRNA methyltransferase activity(+) 2 rec.
           |   |__tRNA methyltransferase activity(+) 23 rec.
           |__S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity
           |__S-adenosylmethionine-dependent methyltransferase activity 127 rec.
           |   |__(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
           |   |__(RS)-norcoclaurine 6-O-methyltransferase activity
           |   |__(S)-coclaurine-N-methyltransferase activity
           |   |__(S)-scoulerine 9-O-methyltransferase activity
           |   |__(S)-tetrahydroprotoberberine N-methyltransferase activity
           |   |__2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity
           |   |__2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity
           |   |__3'-demethylstaurosporine O-methyltransferase activity
           |   |__3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity
           |   |__3,5-dichloro-THPH methyl transferase activity
           |   |__3,7-dimethylquercitin 4'-O-methyltransferase activity
           |   |__3-demethylubiquinol 3-O-methyltransferase activity 1 rec.
           |   |__3-demethylubiquinone 3-O-methyltransferase activity
           |   |__3-hydroxyanthranilate 4-C-methyltransferase activity
           |   |__3-methylquercitin 7-O-methyltransferase activity
           |   |__4-vinylphenol methyltransferase activity
           |   |__5-hydroxyfuranocoumarin 5-O-methyltransferase activity
           |   |__6-hydroxymellein O-methyltransferase activity
           |   |__6-O-methylnorlaudanosoline 5'-O-methyltransferase activity
           |   |__8-hydroxyfuranocoumarin 8-O-methyltransferase activity
           |   |__8-hydroxyquercitin 8-O-methyltransferase activity
           |   |__10-hydroxydihydrosanguinarine 10-O-methyltransferase activity
           |   |__11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity
           |   |__12-hydroxydihydrochelirubine 12-O-methyltransferase activity
           |   |__16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity
           |   |__24-methylenesterol C-methyltransferase activity
           |   |__[cytochrome c]-methionine S-methyltransferase activity
           |   |__[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity
           |   |__acetylserotonin O-methyltransferase activity
           |   |__amine N-methyltransferase activity
           |   |__anthranilate N-methyltransferase activity
           |   |__apigenin 4'-O-methyltransferase activity
           |   |__arginine N-methyltransferase activity(+) 13 rec.
           |   |__arsenite methyltransferase activity
           |   |__caffeoyl-CoA O-methyltransferase activity
           |   |__carnosine N-methyltransferase activity 1 rec.
           |   |__catechol O-methyltransferase activity
           |   |__chlorophenol O-methyltransferase activity
           |   |__columbamine O-methyltransferase activity
           |   |__cycloartenol 24-C-methyltransferase activity
           |   |__cyclopropane-fatty-acyl-phospholipid synthase activity
           |   |__demethylmacrocin O-methyltransferase activity
           |   |__dimethylglycine N-methyltransferase activity
           |   |__diphthine methyl ester synthase activity 1 rec.
           |   |__diphthine synthase activity
           |   |__DNA (cytosine-5-)-methyltransferase activity(+) 1 rec.
           |   |__farnesoic acid O-methyltransferase activity 1 rec.
           |   |__fatty acid O-methyltransferase activity
           |   |__flavone 3'-O-methyltransferase activity
           |   |__glucuronoxylan 4-O-methyltransferase activity
           |   |__glycine N-methyltransferase activity 1 rec.
           |   |__guanidinoacetate N-methyltransferase activity
           |   |__histamine N-methyltransferase activity
           |   |__indolepyruvate C-methyltransferase activity
           |   |__inositol 1-methyltransferase activity
           |   |__inositol 3-methyltransferase activity
           |   |__inositol 4-methyltransferase activity
           |   |__iodophenol O-methyltransferase activity
           |   |__isobutyraldoxime O-methyltransferase activity
           |   |__isoflavone 4'-O-methyltransferase activity
           |   |__isoflavone 7-O-methyltransferase activity
           |   |__isoliquiritigenin 2'-O-methyltransferase activity
           |   |__isoorientin 3'-O-methyltransferase activity
           |   |__kaempferol 4'-O-methyltransferase activity
           |   |__L-histidine N(alpha)-methyltransferase activity
           |   |__laricitrin 5'-O-methyltransferase activity
           |   |__licodione 2'-O-methyltransferase activity
           |   |__lipid A phosphate methyltransferase activity
           |   |__loganate O-methyltransferase activity
           |   |__lysine N-methyltransferase activity(+) 52 rec.
           |   |__macrocin O-methyltransferase activity
           |   |__magnesium protoporphyrin IX methyltransferase activity
           |   |__methionine S-methyltransferase activity
           |   |__methyl jasmonate methylesterase activity
           |   |__methylene-fatty-acyl-phospholipid synthase activity
           |   |__methylquercetagetin 6-O-methyltransferase activity
           |   |__mRNA methyltransferase activity(+) 6 rec.
           |   |__myricetin 3'-O-methyltransferase activity
           |   |__N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity
           |   |__N-terminal protein N-methyltransferase activity 1 rec.
           |   |__nicotinamide N-methyltransferase activity
           |   |__nicotinate N-methyltransferase activity
           |   |__O-demethylpuromycin O-methyltransferase activity
           |   |__phenol O-methyltransferase activity
           |   |__phenylethanolamine N-methyltransferase activity
           |   |__phosphatidyl-N-methylethanolamine N-methyltransferase activity
           |   |__phosphatidylethanolamine N-methyltransferase activity
           |   |__phosphoethanolamine N-methyltransferase activity
           |   |__polyprenyldihydroxybenzoate methyltransferase activity 1 rec.
           |   |__polysaccharide O-methyltransferase activity
           |   |__precorrin-2 C20-methyltransferase activity
           |   |__precorrin-3B C17-methyltransferase activity
           |   |__precorrin-4 C11-methyltransferase activity
           |   |__precorrin-6Y C5,15-methyltransferase (decarboxylating) activity
           |   |__protein C-terminal leucine carboxyl O-methyltransferase activity 1 rec.
           |   |__protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity 1 rec.
           |   |__protein-arginine C-methyltransferase activity
           |   |__protein-cysteine methyltransferase activity 1 rec.
           |   |__protein-glutamate O-methyltransferase activity
           |   |__protein-glutamine N-methyltransferase activity(+) 5 rec.
           |   |__protein-L-histidine N-pros-methyltransferase activity 1 rec.
           |   |__protein-L-histidine N-tele-methyltransferase activity 2 rec.
           |   |__protein-L-isoaspartate (D-aspartate) O-methyltransferase activity 1 rec.
           |   |__putrescine N-methyltransferase activity
           |   |__pyridine N-methyltransferase activity
           |   |__quercetin 3-O-methyltransferase activity
           |   |__RNA 5'-gamma-phosphate methyltransferase activity
           |   |__RNA cap trimethylguanosine synthase activity 1 rec.
           |   |__rRNA methyltransferase activity(+) 21 rec.
           |   |__S-adenosylmethionine-homocysteine S-methyltransferase activity 2 rec.
           |   |__sarcosine N-methyltransferase activity
           |   |__site-specific DNA-methyltransferase (adenine-specific) activity
           |   |__site-specific DNA-methyltransferase (cytosine-N4-specific) activity
           |   |__sterol 24-C-methyltransferase activity
           |   |__tellurite methyltransferase activity
           |   |__tetrahydrocolumbamine 2-O-methyltransferase activity
           |   |__thioether S-methyltransferase activity
           |   |__thiol S-methyltransferase activity
           |   |__thiopurine S-methyltransferase activity
           |   |__trans-aconitate 2-methyltransferase activity
           |   |__trans-aconitate 3-methyltransferase activity
           |   |__tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
           |   |__tRNA (adenine) methyltransferase activity(+) 4 rec.
           |   |__tRNA (cytidine) methyltransferase activity(+) 7 rec.
           |   |__tRNA (guanine) methyltransferase activity(+) 10 rec.
           |   |__tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent 1 rec.
           |   |__tryptophan 2-C-methyltransferase activity
           |   |__tyramine N-methyltransferase activity
           |   |__uroporphyrin-III C-methyltransferase activity
           |   |__vitexin 2''-O-rhamnoside 7-O-methyltransferase activity
           |__S-methyltransferase activity 4 rec.
           |   |__5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
           |   |__betaine-homocysteine S-methyltransferase activity 2 rec.
           |   |__methionine synthase activity
           |   |__methylated-DNA-[protein]-cysteine S-methyltransferase activity 1 rec.
           |   |__protein-cysteine methyltransferase activity 1 rec.
           |   |__S-adenosylmethionine-homocysteine S-methyltransferase activity 2 rec.
           |   |__S-methylmethionine-homocysteine S-methyltransferase activity 2 rec.
           |   |__tetrahydromethanopterin S-methyltransferase activity
           |   |__thetin-homocysteine S-methyltransferase activity
           |   |__thioether S-methyltransferase activity
           |   |__thiol S-methyltransferase activity
           |   |__thiopurine S-methyltransferase activity
           |__scutellarein 7-methyl ether 4'-O-methyltransferase activity
           |__scutellarein 7-methyl ether 6-O-methyltransferase activity
           |__Se-methyltransferase activity
           |   |__selenocysteine methyltransferase activity
           |__selenol Se-methyltransferase activity
           |__syringetin 3-O-methyltransferase activity
           |__syringetin 7-O-methyltransferase activity
           |__thiocyanate methyltransferase activity
           |__TRIBOA-glucoside methyltransferase activity
           |__tricaffeoyl spermidine O-methyltransferase activity
           |__tricetin O-methytransferase activity
           |__trimethylamine methyltransferase activity
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Is a transferase activity, transferring one-carbon groups
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Synonyms
  • "methylase" BROAD
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EC:2.1.1.-
Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3"
Reactome:R-HSA-379387 "COMT transfers Met to DA to form 3MT"
Reactome:R-HSA-379464 "COMT transfers Met to DOPAC to form HVA"
Reactome:R-HSA-5333608 "GSSebGalNac is reduced and methylated to MeSebGalNac"
Reactome:R-HSA-6800149 "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII"
Reactome:R-HSA-71286 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine"
Reactome:R-HSA-9710490 "The GSDME gene promoter is hypermethylated"