FB2026_03 , released September 17, 2026
CV Term Report
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Term tRNA methyltransferase activity ID (Ontology) GO:0008175 (Gene Ontology)
Definition Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 tRNA methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | tRNA methyltransferase activity       --
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methyltransferase activity
 |__RNA methyltransferase activity________
catalytic activity, acting on RNA         |
 |__RNA methyltransferase activity________|
 |__catalytic activity, acting on a tRNA__|
                                          tRNA methyltransferase activity  23 rec.
                                           |__tRNA (adenine) methyltransferase activity 4 rec.
                                           |   |__tRNA (adenine(9)-N1)-methyltransferase activity 1 rec.
                                           |   |__tRNA (adenine(22)-N1)-methyltransferase activity
                                           |   |__tRNA (adenine(37)-C2)-methyltransferase activity
                                           |   |__tRNA (adenine(57)-N1)/(adenine(58)-N1)-methyltransferase activity
                                           |   |__tRNA (adenine(58)-N1)-methyltransferase activity 1 rec.
                                           |   |__tRNA (cytidine(4)/adenine(4)-2'-O-ribose)-methyltransferase activity
                                           |   |__tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity 2 rec.
                                           |   |__tRNA(Val) (adenine(37)-N6)-methyltransferase activity
                                           |__tRNA (cytidine) methyltransferase activity 7 rec.
                                           |   |__tRNA (cytidine(4)/adenine(4)-2'-O-ribose)-methyltransferase activity
                                           |   |__tRNA (cytidine(32)-2'-O-ribose)-methyltransferase activity 1 rec.
                                           |   |__tRNA (cytidine(32)/uridine(32)-2'-O-ribose)-methyltransferase activity
                                           |   |__tRNA (cytidine(34)-2'-O-ribose)-methyltransferase activity 2 rec.
                                           |   |__tRNA (cytidine(56)-2'-O-ribose)-methyltransferase activity
                                           |   |__tRNA (cytidine-N3)-methyltransferase activity 1 rec.
                                           |   |__tRNA (cytidine-N5)-methyltransferase activity 3 rec.
                                           |__tRNA (guanine) methyltransferase activity 10 rec.
                                           |   |__tRNA (guanine(6)-N2)-methyltransferase activity
                                           |   |__tRNA (guanine(7)-N2)-methyltransferase activity
                                           |   |__tRNA (guanine(10)-N2)-dimethyltransferase activity
                                           |   |__tRNA (guanine(10)-N2)-methyltransferase activity 1 rec.
                                           |   |__tRNA (guanine(18)-2'-O-ribose)-methyltransferase activity 1 rec.
                                           |   |__tRNA (guanine(26)-N2)-dimethyltransferase activity 1 rec.
                                           |   |__tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity
                                           |   |__tRNA (guanine(27)-N2)-dimethyltransferase activity
                                           |   |__tRNA (guanine(37)-N1)-methyltransferase activity 1 rec.
                                           |   |__tRNA (guanine(46)-N7)-methyltransferase activity 2 rec.
                                           |   |__tRNA (guanosine(9)-N1)-methyltransferase activity 2 rec.
                                           |   |__tRNA (guanosine(34)-2'-O-ribose)-methyltransferase activity 2 rec.
                                           |__tRNA (uridine) methyltransferase activity 4 rec.
                                               |__tRNA (5-carboxymethoxyuridine(34)-5-O)-methyltransferase activity
                                               |__tRNA (5-carboxymethylaminomethyluridine(34)-2'-O-ribose)-methyltransferase activity
                                               |__tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity 2 rec.
                                               |__tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
                                               |__tRNA (cytidine(32)/uridine(32)-2'-O-ribose)-methyltransferase activity
                                               |__tRNA (uracil(54)-C5)-methyltransferase activity, 5,10-methylenetetrahydrofolate-dependent
                                               |__tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent 1 rec.
                                               |__tRNA(Ser) (uridine(44)-2'-O-ribose)-methyltransferase activity 1 rec.
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Is a RNA methyltransferase activity
catalytic activity, acting on a tRNA
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Reactome:R-HSA-6782879 "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe)"
Reactome:R-HSA-6782881 "LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)"
Reactome:R-HSA-6782890 "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe)"
Reactome:R-HSA-6783473 "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)"
Reactome:R-HSA-6786500 "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34"
Reactome:R-HSA-6786567 "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine"