FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term tRNA (guanine(46)-N7)-methyltransferase activity ID (Ontology) GO:0008176 (Gene Ontology)
Definition Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine.
Also Known As"tRNA (guanine(46)-N7-)-methyltransferase activity" ; "tRNA (guanosine(46)-N(7))-methyltransferase activity" ; "tRNA (guanosine(46)-N7)-methyltransferase activity" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 tRNA (guanine(46)-N7)-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | tRNA (guanine(46)-N7)-methyltransferase activity       --
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tRNA methyltransferase activity____________________________
S-adenosylmethionine-dependent methyltransferase activity__|
                                                           tRNA (guanine) methyltransferase activity
                                                            |__tRNA (guanine(46)-N7)-methyltransferase activity  2 rec.
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Is a tRNA (guanine) methyltransferase activity
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Synonyms
  • "7-methylguanine transfer ribonucleate methylase activity" BROAD[ EC:2 ]
    "N7-methylguanine methylase activity" BROAD[ EC:2 ]
    "tRNA (guanine(46)-N7-)-methyltransferase activity" EXACT
    "tRNA (guanine-N7-)-methyltransferase activity" BROAD
    "tRNA (guanosine(46)-N(7))-methyltransferase activity" EXACT
    "tRNA (guanosine(46)-N7)-methyltransferase activity" EXACT
    "tRNA (guanosine(46)-N7-)-methyltransferase activity" EXACT
    "tRNA guanine 7-methyltransferase activity" BROAD[ EC:2 ]
Secondary IDs
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EC:2.1.1.33
MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
Reactome:R-HSA-6782286 "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46"
RHEA:42708