FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term phosphatidate phosphatase activity ID (Ontology) GO:0008195 (Gene Ontology)
Definition Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.[ PubMed:25814022 ]
Also Known As"phosphatidate phosphohydrolase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 phosphatidate phosphatase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | phosphatidate phosphatase activity
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  phosphatase activity
   |__lipid phosphatase activity
       |__phosphatidate phosphatase activity  9 rec.
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Is a lipid phosphatase activity
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Synonyms
  • "3-sn-phosphatidate phosphohydrolase activity" RELATED[ EC:3 ]
    "acid phosphatidyl phosphatase activity" RELATED[ EC:3 ]
    "phosphatic acid phosphatase activity" RELATED[ EC:3 ]
    "phosphatic acid phosphohydrolase activity" RELATED[ EC:3 ]
    "phosphatidate phosphohydrolase activity" EXACT
    "phosphatidic acid phosphatase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.1.3.4
MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN
Reactome:R-HSA-1483203 "PA is dephosphorylated to DAG by LPIN"
Reactome:R-HSA-163688 "Dephosphorylation of pChREBP (Thr 666) by PP2A"
Reactome:R-HSA-164056 "Dephosphorylation of pChREBP (Ser 556) by PP2A"
Reactome:R-HSA-2029468 "Conversion of PA into DAG by PAP-1"
Reactome:R-HSA-390329 "Dephosphorylation of AKT by PP2A"
Reactome:R-HSA-5221130 "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol"
Reactome:R-HSA-6797630 "LRPP4(LRPP1-3,5) hydrolyse LPA"
Reactome:R-HSA-75899 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate"
RHEA:27429
RHEA:41255
RHEA:42860
RHEA:43236
RHEA:43252
RHEA:43256
RHEA:43260
RHEA:43280
RHEA:43284
RHEA:43296