FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term 5'-nucleotidase activity ID (Ontology) GO:0008253 (Gene Ontology)
Definition Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.[ EC:3 ]
Also Known As "5' nucleotidase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 5'-nucleotidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 5'-nucleotidase activity
 NOT | enables | 5'-nucleotidase activity
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  phosphatase activity
   |__nucleotidase activity
       |__5'-nucleotidase activity  7 rec.
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Synonyms
  • "5' nucleotidase activity" EXACT
    "5'-adenylic phosphatase" NARROW[ EC:3 ]
    "5'-AMP nucleotidase" NARROW[ EC:3 ]
    "5'-AMPase" NARROW[ EC:3 ]
    "5'-mononucleotidase activity" RELATED[ EC:3 ]
    "5'-ribonucleotide phosphohydrolase activity" RELATED[ EC:3 ]
    "adenosine 5'-phosphatase" NARROW[ EC:3 ]
    "adenosine monophosphatase" NARROW[ EC:3 ]
    "AMP phosphatase" NARROW[ EC:3 ]
    "AMP phosphohydrolase" NARROW[ EC:3 ]
    "AMPase" NARROW[ EC:3 ]
    "snake venom 5'-nucleotidase" NARROW[ EC:3 ]
    "thimidine monophosphate nucleotidase" NARROW[ EC:3 ]
    "UMPase" NARROW[ EC:3 ]
    "uridine 5'-nucleotidase" NARROW[ EC:3 ]
Secondary IDs
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EC:3.1.3.5
MetaCyc:5-NUCLEOTID-RXN
Reactome:R-HSA-109278 "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP"
Reactome:R-HSA-109291 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]"
Reactome:R-HSA-109380 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)"
Reactome:R-HSA-109387 "(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]"
Reactome:R-HSA-109415 "AMP + H2O => adenosine + orthophosphate [NT5C1B]"
Reactome:R-HSA-109449 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)"
Reactome:R-HSA-109470 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)"
Reactome:R-HSA-109480 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]"
Reactome:R-HSA-109514 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]"
Reactome:R-HSA-5694126 "NT5C3B hydrolyses 7MGP to 7MG"
Reactome:R-HSA-74248 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)"
Reactome:R-HSA-8940070 "NT5E:Zn2+ hydrolyses NAD+"
Reactome:R-HSA-8940074 "NT5E:Zn2+ hydrolyses NMN"
Reactome:R-HSA-9755078 "NT5C2 tetramer dephosphorylates RBV-MP"
RHEA:12484
RHEA:27714
RHEA:27718
RHEA:29359
RHEA:29375
RHEA:30815