FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term cohesin complex ID (Ontology) GO:0008278 (Gene Ontology)
Definition A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).[ PubMed:9887095 ]
Also Known As "SMC/kleisin ring complex"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
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 cohesin complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | cohesin complex       --
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cellular_component
 |__protein-containing complex________
intracellular membraneless organelle  |
 |__chromosome________________________|
                                      cohesin complex  11 rec.
                                       |__meiotic cohesin complex 2 rec.
                                       |__mitotic cohesin complex 5 rec.
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Is a protein-containing complex
Part of chromosome
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Synonyms
  • "14S cohesin" NARROW
    "9S cohesin" NARROW
    "cohesin core heterodimer" RELATED
    "nuclear cohesin complex" RELATED
    "SMC complex" RELATED
    "SMC/kleisin ring complex" EXACT
    "Smc1-Smc3 complex" NARROW
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