FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term MAP kinase kinase kinase kinase activity ID (Ontology) GO:0008349 (Gene Ontology)
Definition Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.[ PubMed:11790549 ]
Also Known As "MAP4K activity" ; "MAPKKKK"
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Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
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 MAP kinase kinase kinase kinase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | MAP kinase kinase kinase kinase activity       2
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  protein kinase activity
   |__protein serine/threonine kinase activity
       |__MAP kinase kinase kinase kinase activity  2 rec.
           |__JUN kinase kinase kinase kinase activity 1 rec.
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Is a protein serine/threonine kinase activity
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Reactome:R-HSA-177692 "Activation of recruited TAK1 within the activated TLR3 complex"
Reactome:R-HSA-936991 "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3"
Reactome:R-HSA-9645442 "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex"