FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

MAP kinase kinase kinase kinase activity

ID (Ontology)

GO:0008349 (Gene Ontology)

Definition

Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.[ PubMed:11790549 ]

Also Known As

"MAP4K activity" ; "MAPKKKK"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
MAP kinase kinase kinase kinase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| MAP kinase kinase kinase kinase activity

Spanning Tree (Parents/Children)

  protein kinase activity
   |__protein serine/threonine kinase activity
       |__MAP kinase kinase kinase kinase activity  2 rec.
           |__JUN kinase kinase kinase kinase activity 1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	protein serine/threonine kinase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"MAP4K activity" EXACT[ PubMed:20811974 ] "MAPKKKK" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-177692 "Activation of recruited TAK1 within the activated TLR3 complex" Reactome:R-HSA-936991 "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3" Reactome:R-HSA-9645442 "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex"