FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term RNA polymerase II CTD heptapeptide repeat kinase activity ID (Ontology) GO:0008353 (Gene Ontology)
Definition Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.[ EC:2 PubMed:28248323 ]
Also Known As "RNA polymerase II carboxy-terminal domain kinase activity"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       3
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 RNA polymerase II CTD heptapeptide repeat kinase activity (all annotations which use CV term, excluding "NOT" statements)       2      3
     enables | RNA polymerase II CTD heptapeptide repeat kinase activity       --       3
Spanning Tree (Parents/Children)
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protein kinase activity
 |__protein serine/threonine kinase activity______________________
catalytic activity, acting on a protein                           |
 |__RNA polymerase II CTD heptapeptide repeat modifying activity__|
                                                                  RNA polymerase II CTD heptapeptide repeat kinase activity  5 rec.
                                                                   |__RNA polymerase II CTD heptapeptide repeat S2 kinase activity
                                                                   |__RNA polymerase II CTD heptapeptide repeat S5 kinase activity
                                                                   |__RNA polymerase II CTD heptapeptide repeat S7 kinase activity
                                                                   |__RNA polymerase II CTD heptapeptide repeat T4 kinase activity
                                                                   |__RNA polymerase II CTD heptapeptide repeat Y1 kinase activity
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Is a protein serine/threonine kinase activity
RNA polymerase II CTD heptapeptide repeat modifying activity
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Synonyms
  • "[RNA-polymerase]-subunit kinase activity" BROAD
    "CTD kinase activity" RELATED[ EC:2 ]
    "RNA polymerase II carboxy-terminal domain kinase activity" EXACT
    "RNA polymerase subunit kinase activity" BROAD[ EC:2 ]
    "RNA-polymerase-subunit kinase activity" BROAD[ EC:2 ]
Secondary IDs
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EC:2.7.11.23
MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN
Reactome:R-HSA-167191 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex"
Reactome:R-HSA-170704 "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex"
Reactome:R-HSA-170706 "Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex"
RHEA:10216