FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term IkappaB kinase activity ID (Ontology) GO:0008384 (Gene Ontology)
Definition Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.[ EC:2 ]
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 IkappaB kinase activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | IkappaB kinase activity
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  protein kinase activity
   |__protein serine/threonine kinase activity
       |__IkappaB kinase activity  1 rec.
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Is a protein serine/threonine kinase activity
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Synonyms
  • "ATP:IkappaB protein phosphotransferase activity" RELATED[ EC:2 ]
    "CHUK" RELATED[ EC:2 ]
    "IKBKA" RELATED[ EC:2 ]
    "IKBKB" RELATED[ EC:2 ]
    "IKK" RELATED[ EC:2 ]
    "IKK-1" RELATED[ EC:2 ]
    "IKK-2" RELATED[ EC:2 ]
    "inhibitor of NF-kappaB kinase activity" RELATED[ EC:2 ]
    "inhibitor of NFkappaB kinase activity" RELATED[ EC:2 ]
    "STK12" RELATED[ EC:2 ]
    "TANK-binding kinase 1 activity" NARROW[ EC:2 ]
    "TBK1" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.11.10
MetaCyc:2.7.11.10-RXN
Reactome:R-HSA-5684267 "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex"
Reactome:R-HSA-5684275 "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400"
RHEA:19073