FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term IkappaB kinase complex ID (Ontology) GO:0008385 (Gene Ontology)
Definition A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.[ PubMed:12055104 PubMed:20300203 ]
Also Known As"heterotrimeric IKK complex" ; "IKK complex" ; "trimeric IKK complex"
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 IkappaB kinase complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | IkappaB kinase complex
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cytoplasm
 |__cytosol__________________________________
cellular anatomical structure                |
 |__cytosol__________________________________|
protein kinase complex                       |
 |__serine/threonine protein kinase complex__|
                                             IkappaB kinase complex  1 rec.
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Is a serine/threonine protein kinase complex
Part of cytosol
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Synonyms
  • "heterotrimeric IKK complex" EXACT
    "IKK complex" EXACT
    "trimeric IKK complex" EXACT[ PubMed:21173796 ]
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