FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term steroid hydroxylase activity ID (Ontology) GO:0008395 (Gene Ontology)
Definition Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.[ ISBN:0721662544 ]
Also Known As "steroid monooxygenase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 steroid hydroxylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | steroid hydroxylase activity
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Vocabulary search: maintenance 
  oxidoreductase activity
   |__monooxygenase activity
       |__steroid hydroxylase activity  6 rec.
           |__cholesterol 25-hydroxylase activity
           |__cholesterol 26-hydroxylase activity
           |__cholesterol monooxygenase (side-chain-cleaving) activity
           |__ecdysone 20-monooxygenase activity 1 rec.
           |__ecdysteroid 2-hydroxylase activity 1 rec.
           |__ecdysteroid 22-hydroxylase activity 1 rec.
           |__ecdysteroid 25-hydroxylase activity 1 rec.
           |__estradiol 6-beta-monooxygenase activity
           |__estrogen 2-hydroxylase activity
           |__estrogen 16-alpha-hydroxylase activity
           |__progesterone monooxygenase activity
           |   |__progesterone 11-alpha-monooxygenase activity
           |__steroid 7-alpha-hydroxylase activity
           |   |__24S-hydroxycholesterol 7-alpha-hydroxylase activity
           |   |__25-hydroxycholesterol 7-alpha-hydroxylase activity
           |   |__cholesterol 7-alpha-monooxygenase activity
           |   |__oxysterol 7-alpha-hydroxylase activity
           |__steroid 9-alpha-monooxygenase activity
           |__steroid 11-beta-monooxygenase activity
           |__steroid 15-alpha-hydroxylase activity
           |__steroid 17-alpha-monooxygenase activity
           |   |__androst-4-ene-3,17-dione monooxygenase activity
           |__steroid 21-monooxygenase activity
           |   |__17-hydroxyprogesterone 21-hydroxylase activity
           |   |__progesterone 21-hydroxylase activity
           |__steroid 22S-hydroxylase activity
           |__sterol 12-alpha-hydroxylase activity
           |__testosterone 6-beta-hydroxylase activity
           |__testosterone 16-alpha-hydroxylase activity
           |__testosterone 16-beta-hydroxylase activity
           |__vitamin D 23-hydroxylase activity
           |   |__1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
           |   |__25-hydroxycholecalciferol-23-hydroxylase activity
           |__vitamin D 24-hydroxylase activity 1 rec.
           |   |__1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 1 rec.
           |   |__25-hydroxycholecalciferol-24-hydroxylase activity
           |__vitamin D 25-hydroxylase activity
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Is a monooxygenase activity
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Synonyms
  • "cytochrome P450 CYP2G1" NARROW
    "olfactory-specific steroid hydroxylase activity" NARROW
    "steroid monooxygenase activity" EXACT
Secondary IDs
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Reactome:R-HSA-191983 "Cholesterol is hydroxylated to 25-hydroxycholesterol"
Reactome:R-HSA-191999 "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol"
Reactome:R-HSA-192042 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al"
Reactome:R-HSA-192054 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)"
Reactome:R-HSA-192123 "CYP27A1 27-hydroxylates CHOL"
Reactome:R-HSA-193060 "CYP19A1 hydroxylates ANDST to E1"
Reactome:R-HSA-193143 "CYP19A1 hydroxylates TEST to EST17b"
Reactome:R-HSA-193393 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol"
Reactome:R-HSA-193460 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)"
Reactome:R-HSA-193497 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al"
Reactome:R-HSA-193713 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)"
Reactome:R-HSA-193719 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al"
Reactome:R-HSA-193737 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)"
Reactome:R-HSA-193780 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al"
Reactome:R-HSA-193787 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol"
Reactome:R-HSA-193792 "CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol"
Reactome:R-HSA-193965 "CYP11B2 oxidises 18HCORST to ALDO"
Reactome:R-HSA-193995 "CYP11B2 18-hydroxylates CORST to 18HCORST"
Reactome:R-HSA-5601849 "Defective CYP19A1 does not convert ANDST to E1"
Reactome:R-HSA-5602170 "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol"
Reactome:R-HSA-6785244 "Defective CYP11B2 does not oxidise 18HCORST"
Reactome:R-HSA-6785245 "Defective CYP11B2 does not oxidise CORST"
Reactome:R-HSA-9035960 "Defective CYP27A1 does not 27-hydroxylate 5-CHOL3,7,24(s)-triol"
Reactome:R-HSA-9758674 "CYP3A4 oxidizes PREDN,PREDL"