FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term steroid hydroxylase activity ID (Ontology) GO:0008395 (Gene Ontology)
Definition Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.[ ISBN:0721662544 ]
Also Known As "steroid monooxygenase activity"
Comment
Links to External Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       2
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 steroid hydroxylase activity (all annotations which use CV term, excluding "NOT" statements)       2
     enables | steroid hydroxylase activity       2
Spanning Tree (Parents/Children)
Only view relationship: 
  oxidoreductase activity
   |__monooxygenase activity
       |__steroid hydroxylase activity  6 rec.
           |__cholesterol 25-hydroxylase activity
           |__cholesterol 26-hydroxylase activity
           |__cholesterol monooxygenase (side-chain-cleaving) activity
           |__ecdysone 20-monooxygenase activity 1 rec.
           |__ecdysteroid 2-hydroxylase activity 1 rec.
           |__ecdysteroid 22-hydroxylase activity 1 rec.
           |__ecdysteroid 25-hydroxylase activity 1 rec.
           |__estradiol 6-beta-monooxygenase activity
           |__estrogen 2-hydroxylase activity
           |__estrogen 16-alpha-hydroxylase activity
           |__progesterone monooxygenase activity
           |   |__progesterone 11-alpha-monooxygenase activity
           |__steroid 7-alpha-hydroxylase activity
           |   |__24S-hydroxycholesterol 7-alpha-hydroxylase activity
           |   |__25-hydroxycholesterol 7-alpha-hydroxylase activity
           |   |__cholesterol 7-alpha-monooxygenase activity
           |   |__oxysterol 7-alpha-hydroxylase activity
           |__steroid 9-alpha-monooxygenase activity
           |__steroid 11-beta-monooxygenase activity
           |__steroid 15-alpha-hydroxylase activity
           |__steroid 17-alpha-monooxygenase activity
           |   |__androst-4-ene-3,17-dione monooxygenase activity
           |__steroid 21-monooxygenase activity
           |   |__17-hydroxyprogesterone 21-hydroxylase activity
           |   |__progesterone 21-hydroxylase activity
           |__steroid 22S-hydroxylase activity
           |__sterol 12-alpha-hydroxylase activity
           |__testosterone 6-beta-hydroxylase activity
           |__testosterone 16-alpha-hydroxylase activity
           |__testosterone 16-beta-hydroxylase activity
           |__vitamin D 23-hydroxylase activity
           |   |__1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
           |   |__25-hydroxycholecalciferol-23-hydroxylase activity
           |__vitamin D 24-hydroxylase activity 1 rec.
           |   |__1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 1 rec.
           |   |__25-hydroxycholecalciferol-24-hydroxylase activity
           |__vitamin D 25-hydroxylase activity
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Is a monooxygenase activity
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Synonyms
  • "cytochrome P450 CYP2G1" NARROW
    "olfactory-specific steroid hydroxylase activity" NARROW
    "steroid monooxygenase activity" EXACT
Secondary IDs
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Reactome:R-HSA-191983 "Cholesterol is hydroxylated to 25-hydroxycholesterol"
Reactome:R-HSA-191999 "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol"
Reactome:R-HSA-192042 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al"
Reactome:R-HSA-192054 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)"
Reactome:R-HSA-192123 "CYP27A1 27-hydroxylates CHOL"
Reactome:R-HSA-193060 "CYP19A1 hydroxylates ANDST to E1"
Reactome:R-HSA-193143 "CYP19A1 hydroxylates TEST to EST17b"
Reactome:R-HSA-193393 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol"
Reactome:R-HSA-193460 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)"
Reactome:R-HSA-193497 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al"
Reactome:R-HSA-193713 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)"
Reactome:R-HSA-193719 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al"
Reactome:R-HSA-193737 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)"
Reactome:R-HSA-193780 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al"
Reactome:R-HSA-193787 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol"
Reactome:R-HSA-193792 "CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol"
Reactome:R-HSA-193965 "CYP11B2 oxidises 18HCORST to ALDO"
Reactome:R-HSA-193995 "CYP11B2 18-hydroxylates CORST to 18HCORST"
Reactome:R-HSA-5601849 "Defective CYP19A1 does not convert ANDST to E1"
Reactome:R-HSA-5602170 "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol"
Reactome:R-HSA-6785244 "Defective CYP11B2 does not oxidise 18HCORST"
Reactome:R-HSA-6785245 "Defective CYP11B2 does not oxidise CORST"
Reactome:R-HSA-9035960 "Defective CYP27A1 does not 27-hydroxylate 5-CHOL3,7,24(s)-triol"
Reactome:R-HSA-9758674 "CYP3A4 oxidizes PREDN,PREDL"