FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

3'-5' exonuclease activity

ID (Ontology)

GO:0008408 (Gene Ontology)

Definition

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.

Also Known As

"3'-5'-exonuclease activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Results list data from multiple species. Choose a record type above to open its HitList.

Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
3'-5' exonuclease activity (all annotations which use CV term, excluding "NOT" statements)
enables \| 3'-5' exonuclease activity	--
NOT \| enables \| 3'-5' exonuclease activity	--

Spanning Tree (Parents/Children)

nuclease activity__________________________
hydrolase activity, acting on ester bonds__|
                                           exonuclease activity
                                            |__3'-5' exonuclease activity  42 rec.
                                                |__3'-5'-DNA exonuclease activity 18 rec.
                                                |   |__double-stranded DNA 3'-5' DNA exonuclease activity 4 rec.
                                                |   |__single-stranded DNA 3'-5' DNA exonuclease activity 8 rec.
                                                |__3'-5'-RNA exonuclease activity 21 rec.
                                                    |__3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing
                                                    |__exoribonuclease II activity
                                                    |__poly(A)-specific ribonuclease activity 6 rec.
                                                    |__poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends 1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	exonuclease activity
Part of
Synonyms & Secondary IDs
Synonyms
	"3'-5'-exonuclease activity" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-3245943 "Viral DNA cleavage by TREX1"