FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term inositol-1,4,5-trisphosphate 3-kinase activity ID (Ontology) GO:0008440 (Gene Ontology)
Definition Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 inositol-1,4,5-trisphosphate 3-kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | inositol-1,4,5-trisphosphate 3-kinase activity
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phosphotransferase activity, alcohol group as acceptor__
inositol phosphate kinase activity______________________|
                                                        inositol trisphosphate kinase activity
                                                         |__inositol-1,4,5-trisphosphate 3-kinase activity  3 rec.
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Is a inositol trisphosphate kinase activity
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Synonyms
  • "1D-myo-inositol-trisphosphate 3-kinase activity" BROAD
    "inositol trisphosphate 3-kinase activity" BROAD
    "inositol-trisphosphate 3-kinase activity" BROAD
    "Ins(1,4,5)P3 3-kinase activity" RELATED[ EC:2 ]
    "IP3 3-kinase activity" NARROW[ EC:2 ]
    "IP3K activity" NARROW[ EC:2 ]
Secondary IDs
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EC:2.7.1.127
KEGG_REACTION:R03433
MetaCyc:2.7.1.127-RXN
Reactome:R-HSA-1855153 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol"
Reactome:R-HSA-1855233 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus"
RHEA:11020