FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term 3-hydroxyisobutyrate dehydrogenase activity ID (Ontology) GO:0008442 (Gene Ontology)
Definition Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+.[ EC:1 ]
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 3-hydroxyisobutyrate dehydrogenase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | 3-hydroxyisobutyrate dehydrogenase activity       1
Spanning Tree (Parents/Children)
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  oxidoreductase activity, acting on CH-OH group of donors
   |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
       |__3-hydroxyisobutyrate dehydrogenase activity  1 rec.
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Is a oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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EC:1.1.1.31
MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN
Reactome:R-HSA-508473 "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+"
Reactome:R-HSA-70885 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+"
RHEA:17681