FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term N-acetylglucosamine-6-sulfatase activity ID (Ontology) GO:0008449 (Gene Ontology)
Definition Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.[ EC:3 ]
Also Known As "N-acetylglucosamine-6-sulphatase activity"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       3
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 Gene Groups Genes
 N-acetylglucosamine-6-sulfatase activity (all annotations which use CV term, excluding "NOT" statements)       1      3
     enables | N-acetylglucosamine-6-sulfatase activity       --       3
Spanning Tree (Parents/Children)
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  hydrolase activity, acting on ester bonds
   |__sulfuric ester hydrolase activity
       |__N-acetylglucosamine-6-sulfatase activity  4 rec.
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Is a sulfuric ester hydrolase activity
Part of
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Synonyms
  • "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" RELATED[ EC:3 ]
    "acetylglucosamine 6-sulfatase activity" RELATED[ EC:3 ]
    "chondroitinsulfatase" BROAD[ EC:3 ]
    "glucosamine-6-sulfatase activity" RELATED[ EC:3 ]
    "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" RELATED[ EC:3 ]
    "N-acetylglucosamine 6-sulfate sulfatase activity" RELATED[ EC:3 ]
    "N-acetylglucosamine-6-sulphatase activity" EXACT
    "O,N-disulfate O-sulfohydrolase activity" RELATED[ EC:3 ]
Secondary IDs
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EC:3.1.6.14
MetaCyc:3.1.6.14-RXN
Reactome:R-HSA-1638032 "GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate"
Reactome:R-HSA-2263495 "Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S"