FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

N-acetylglucosamine-6-sulfatase activity

ID (Ontology)

GO:0008449 (Gene Ontology)

Definition

Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.[ EC:3 ]

Also Known As

"N-acetylglucosamine-6-sulphatase activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Gene Groups	Genes
N-acetylglucosamine-6-sulfatase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| N-acetylglucosamine-6-sulfatase activity	--

Spanning Tree (Parents/Children)

  hydrolase activity, acting on ester bonds
   |__sulfuric ester hydrolase activity
       |__N-acetylglucosamine-6-sulfatase activity  4 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	sulfuric ester hydrolase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" RELATED[ EC:3 ] "acetylglucosamine 6-sulfatase activity" RELATED[ EC:3 ] "chondroitinsulfatase" BROAD[ EC:3 ] "glucosamine-6-sulfatase activity" RELATED[ EC:3 ] "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" RELATED[ EC:3 ] "N-acetylglucosamine 6-sulfate sulfatase activity" RELATED[ EC:3 ] "N-acetylglucosamine-6-sulphatase activity" EXACT "O,N-disulfate O-sulfohydrolase activity" RELATED[ EC:3 ]
Secondary IDs

External Crossreferences & Linkouts
	EC:3.1.6.14 MetaCyc:3.1.6.14-RXN Reactome:R-HSA-1638032 "GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate" Reactome:R-HSA-2263495 "Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S"