FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term 3-methylbutanoyl-CoA dehydrogenase activity ID (Ontology) GO:0008470 (Gene Ontology)
Definition Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein].[ PubMed:25450250 PubMed:7640268 ]
Also Known As"isovaleryl-CoA dehydrogenase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 3-methylbutanoyl-CoA dehydrogenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 3-methylbutanoyl-CoA dehydrogenase activity
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  acyl-CoA dehydrogenase activity
   |__short-chain fatty acyl-CoA dehydrogenase activity
       |__3-methylbutanoyl-CoA dehydrogenase activity  1 rec.
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Is a short-chain fatty acyl-CoA dehydrogenase activity
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Synonyms
  • "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" RELATED[ EC:1 ]
    "3-methylbutanoyl-CoA:acceptor oxidoreductase activity" RELATED[ EC:1 ]
    "isovaleroyl-coenzyme A dehydrogenase activity" RELATED[ EC:1 ]
    "isovaleryl-CoA dehydrogenase activity" EXACT
    "isovaleryl-coenzyme A dehydrogenase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.3.8.4
MetaCyc:RXN0-2301
Reactome:R-HSA-70745 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2"
Reactome:R-HSA-9914837 "IVD mutants don't synthesize beta-methylcrotonyl-CoA"
RHEA:12276