FB2026_03 , released September 17, 2026
CV Term Report
Help Close All Open All
General Information
Term palmitoyl-(protein) hydrolase activity ID (Ontology) GO:0008474 (Gene Ontology)
Definition Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.[ EC:3 ]
Also Known As"palmitoyl-protein hydrolase activity" ; "palmitoyl-protein thioesterase activity" ; "palmitoyl-protein thiolesterase activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS

Choose a record type to view annotations for this term and its child terms. Direct annotations and full annotation statements below also provide HitList buttons.

    • Results list data from multiple species. Choose a record type above to open its HitList.
Direct annotations: records annotated with this exact term (child terms are NOT included)
Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 palmitoyl-(protein) hydrolase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | palmitoyl-(protein) hydrolase activity       --
Spanning Tree (Parents/Children)
Only view relationship:
Vocabulary search 
catalytic activity
 |__catalytic activity, acting on a protein__
hydrolase activity                           |
 |__palmitoyl hydrolase activity_____________|
hydrolase activity, acting on ester bonds    |
 |__thiolester hydrolase activity____________|
                                             palmitoyl-(protein) hydrolase activity  6 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a thiolester hydrolase activity
palmitoyl hydrolase activity
catalytic activity, acting on a protein
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "palmitoyl-[protein] hydrolase" BROAD[ EC:3 ]
    "palmitoyl-protein hydrolase activity" EXACT
    "palmitoyl-protein thioesterase activity" EXACT
    "palmitoyl-protein thiolesterase activity" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
EC:3.1.2.22
MetaCyc:3.1.2.22-RXN
Reactome:R-HSA-203613 "Depalmitoylation of eNOS"
Reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins"
Reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43"
Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated"
RHEA:19233