FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term palmitoyl-(protein) hydrolase activity ID (Ontology) GO:0008474 (Gene Ontology)
Definition Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.[ EC:3 ]
Also Known As "palmitoyl-protein hydrolase activity" ; "palmitoyl-protein thioesterase activity" ; "palmitoyl-protein thiolesterase activity"
Comment
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       5
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 palmitoyl-(protein) hydrolase activity (all annotations which use CV term, excluding "NOT" statements)       1      5
     enables | palmitoyl-(protein) hydrolase activity       --       5
Spanning Tree (Parents/Children)
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catalytic activity
 |__catalytic activity, acting on a protein__
hydrolase activity                           |
 |__palmitoyl hydrolase activity_____________|
hydrolase activity, acting on ester bonds    |
 |__thiolester hydrolase activity____________|
                                             palmitoyl-(protein) hydrolase activity  6 rec.
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Is a thiolester hydrolase activity
palmitoyl hydrolase activity
catalytic activity, acting on a protein
Part of
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Synonyms
  • "palmitoyl-[protein] hydrolase" BROAD[ EC:3 ]
    "palmitoyl-protein hydrolase activity" EXACT
    "palmitoyl-protein thioesterase activity" EXACT
    "palmitoyl-protein thiolesterase activity" EXACT
Secondary IDs
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EC:3.1.2.22
MetaCyc:3.1.2.22-RXN
Reactome:R-HSA-203613 "Depalmitoylation of eNOS"
Reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins"
Reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43"
Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated"
RHEA:19233