FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term procollagen-lysine 5-dioxygenase activity ID (Ontology) GO:0008475 (Gene Ontology)
Definition Catalysis of the reaction: L-lysyl-[collagen] + 2-oxoglutarate + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + succinate + CO2.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 procollagen-lysine 5-dioxygenase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | procollagen-lysine 5-dioxygenase activity
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catalytic activity
 |__catalytic activity, acting on a protein____________________________________________________________
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  |
 |__2-oxoglutarate-dependent dioxygenase activity______________________________________________________|
dioxygenase activity                                                                                   |
 |__2-oxoglutarate-dependent dioxygenase activity______________________________________________________|
                                                                                         procollagen-lysine 5-dioxygenase activity  1 rec.
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Is a 2-oxoglutarate-dependent dioxygenase activity
catalytic activity, acting on a protein
Part of
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Synonyms
  • "collagen lysine hydroxylase activity" RELATED[ EC:1 ]
    "lysine hydroxylase activity" BROAD[ EC:1 ]
    "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD[ EC:1 ]
    "lysine-2-oxoglutarate dioxygenase activity" BROAD[ EC:1 ]
    "lysyl hydroxylase activity" BROAD[ EC:1 ]
    "lysylprotocollagen dioxygenase activity" RELATED[ EC:1 ]
    "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)" RELATED[ EC:1 ]
    "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity" RELATED[ EC:1 ]
    "protocollagen lysine dioxygenase activity" RELATED[ EC:1 ]
    "protocollagen lysine hydroxylase activity" RELATED[ EC:1 ]
    "protocollagen lysyl hydroxylase activity" RELATED[ EC:1 ]
Secondary IDs
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EC:1.14.11.4
MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN
Reactome:R-HSA-1981104 "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines"
RHEA:16569