FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term tRNA-guanosine(34) queuine transglycosylase activity ID (Ontology) GO:0008479 (Gene Ontology)
Definition Catalysis of the reaction: guanosine34 in tRNA + queuine = guanine + queuosine34 in tRNA.
Also Known As"eTGT" ; "queuine tRNA-ribosyltransferase" ; "queuine(34) transfer ribonucleate ribosyltransferase" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 tRNA-guanosine(34) queuine transglycosylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | tRNA-guanosine(34) queuine transglycosylase activity       --
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glycosyltransferase activity
 |__pentosyltransferase activity__________
catalytic activity, acting on RNA         |
 |__catalytic activity, acting on a tRNA__|
                                          tRNA-guanosine(34) queuine transglycosylase activity  2 rec.
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Is a pentosyltransferase activity
catalytic activity, acting on a tRNA
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Synonyms
  • "eTGT" EXACT
    "guanine insertion enzyme" RELATED[ EC:2 ]
    "Q-insertase" BROAD[ EC:2 ]
    "queuine tRNA-ribosyltransferase" EXACT[ EC:2 ]
    "queuine tRNA-ribosyltransferase activity" BROAD
    "queuine(34) transfer ribonucleate ribosyltransferase" EXACT[ EC:2 ]
    "TGT" BROAD[ EC:2 ]
    "tRNA guanine transglycosylase" BROAD
    "tRNA transglycosylase" BROAD[ EC:2 ]
    "tRNA-guanosine(34) queuine transglycosylase" EXACT[ EC:2 ]
Secondary IDs
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EC:2.4.2.64
MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN
Reactome:R-HSA-6782443 "QTRT1:QTRTD1 exchanges guanine for queuine at guanosine-34 of tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr) yielding queuosine-34 tRNA(Asn),tRNA(Asp),tRNA(His),tRNA(Tyr)"
RHEA:16633
RHEA:78299
RHEA:78303