FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term sphingosine kinase activity ID (Ontology) GO:0008481 (Gene Ontology)
Definition Catalysis of the reaction: a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H+.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 sphingosine kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | sphingosine kinase activity       --
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kinase activity
 |__lipid kinase activity________________________________________
transferase activity, transferring phosphorus-containing groups  |
 |__phosphotransferase activity, alcohol group as acceptor_______|
                                                                 sphingosine kinase activity  3 rec.
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Is a lipid kinase activity
phosphotransferase activity, alcohol group as acceptor
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Synonyms
  • "ATP:sphinganine 1-phosphotransferase activity" RELATED[ EC:2 ]
    "dihydrosphingosine kinase (phosphorylating)" RELATED[ EC:2 ]
    "dihydrosphingosine kinase activity" RELATED[ EC:2 ]
    "sphinganine kinase activity" RELATED
    "sphingosine kinase (phosphorylating)" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.1.91
MetaCyc:SPHINGANINE-KINASE-RXN
Reactome:R-HSA-5218845 "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate"
Reactome:R-HSA-9625814 "SPHK1 phosphorylates sphingosine in response to E2 stimulation"
RHEA:15465
RHEA:33563
RHEA:34715
RHEA:34747
RHEA:35847
RHEA:51496
RHEA:63956