FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term protoheme IX farnesyltransferase activity ID (Ontology) GO:0008495 (Gene Ontology)
Definition Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate.
Also Known As"haem O synthase activity" ; "heme A:farnesyltransferase activity" ; "heme O synthase activity" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 protoheme IX farnesyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | protoheme IX farnesyltransferase activity
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  transferase activity, transferring alkyl or aryl (other than methyl) groups
   |__prenyltransferase activity
       |__protoheme IX farnesyltransferase activity  1 rec.
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Is a prenyltransferase activity
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Synonyms
  • "haem O synthase activity" EXACT
    "heme A:farnesyltransferase activity" EXACT[ PubMed:9177788 ]
    "heme O synthase activity" EXACT
    "protohaem IX farnesyltransferase activity" EXACT
Secondary IDs
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EC:2.5.1.141
MetaCyc:HEMEOSYN-RXN
Reactome:R-HSA-2995330 "COX10 transforms heme to heme O"
RHEA:28070