FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term oxidized purine nucleobase lesion DNA N-glycosylase activity ID (Ontology) GO:0008534 (Gene Ontology)
Definition Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.[ PubMed:11554296 ]
Also Known As"oxidized purine base lesion DNA N-glycosylase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 oxidized purine nucleobase lesion DNA N-glycosylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | oxidized purine nucleobase lesion DNA N-glycosylase activity
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  DNA N-glycosylase activity
   |__oxidized base lesion DNA N-glycosylase activity
       |__oxidized purine nucleobase lesion DNA N-glycosylase activity  2 rec.
           |__8-oxo-7,8-dihydroguanine DNA N-glycosylase activity 1 rec.
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Is a oxidized base lesion DNA N-glycosylase activity
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Synonyms
  • "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" RELATED[ EC:3 ]
    "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" RELATED[ EC:3 ]
    "8-oxoguanine DNA glycosylase activity" BROAD
    "bifunctional DNA glycosylase activity" BROAD
    "deoxyribonucleate glycosidase activity" RELATED[ EC:3 ]
    "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED
    "DNA glycosylase/AP-lyase activity" BROAD
    "DNA glycosylase/beta-lyase activity" BROAD
    "DNA-formamidopyrimidine glycosylase activity" RELATED
    "Fapy-DNA glycosylase activity" RELATED[ EC:3 ]
    "formamidopyrimidine-DNA glycosylase activity" RELATED
    "Fpg protein" RELATED[ EC:3 ]
    "oxidized purine base lesion DNA N-glycosylase activity" EXACT
    "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED
Secondary IDs
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EC:3.2.2.23
MetaCyc:3.2.2.23-RXN
Reactome:R-HSA-110229 "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase"
Reactome:R-HSA-110243 "Excision of 8-oxoguanine by OGG1 glycosylase"
Reactome:R-HSA-110244 "Excision of FapyG by OGG1 glycosylase"