FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

JUN kinase kinase activity

ID (Ontology)

GO:0008545 (Gene Ontology)

Definition

Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase.[ PubMed:11057897 PubMed:11790549 ]

Also Known As

"JNKK"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
JUN kinase kinase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| JUN kinase kinase activity

Spanning Tree (Parents/Children)

  protein serine/threonine/tyrosine kinase activity
   |__MAP kinase kinase activity
       |__JUN kinase kinase activity  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	MAP kinase kinase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"JNKK" EXACT
Secondary IDs

External Crossreferences & Linkouts
	Reactome:R-HSA-168162 "Phosphorylation of human JNKs by activated MKK4/MKK7"