FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term JUN kinase kinase activity ID (Ontology) GO:0008545 (Gene Ontology)
Definition Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase.[ PubMed:11057897 PubMed:11790549 ]
Also Known As "JNKK"
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
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 Genes
 JUN kinase kinase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | JUN kinase kinase activity       1
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  protein serine/threonine/tyrosine kinase activity
   |__MAP kinase kinase activity
       |__JUN kinase kinase activity  1 rec.
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Is a MAP kinase kinase activity
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Synonyms
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Secondary IDs
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Reactome:R-HSA-168162 "Phosphorylation of human JNKs by activated MKK4/MKK7"