FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

intrinsic apoptotic signaling pathway in response to DNA damage

ID (Ontology)

GO:0008630 (Gene Ontology)

Definition

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_BIOLOGICAL_PROCESS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
intrinsic apoptotic signaling pathway in response to DNA damage (all annotations which use CV term, excluding "NOT" statements)
involved_in \| intrinsic apoptotic signaling pathway in response to DNA damage

Spanning Tree (Parents/Children)

cellular response to stress
 |__DNA damage response____________________
intracellular signal transduction          |
 |__intrinsic apoptotic signaling pathway__|
apoptotic signaling pathway                |
 |__intrinsic apoptotic signaling pathway__|
                                           intrinsic apoptotic signaling pathway in response to DNA damage  13 rec.
                                            |__intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 6 rec.
                                            |   |__regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(+) 3 rec.
                                            |__regulation of intrinsic apoptotic signaling pathway in response to DNA damage 3 rec.
                                                |__negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(+) 2 rec.
                                                |__positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(+) 1 rec.
                                                |__regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(+) 3 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	DNA damage response intrinsic apoptotic signaling pathway
Part of
Synonyms & Secondary IDs
Synonyms
	"DNA damage response, signal transduction resulting in induction of apoptosis" RELATED
Secondary IDs

External Crossreferences & Linkouts