FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term S-adenosylmethionine-dependent methyltransferase activity ID (Ontology) GO:0008757 (Gene Ontology)
Definition Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
Also Known As"S-adenosyl methionine-dependent methyltransferase activity" ; "SAM-dependent methyltransferase activity"
Comment
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 S-adenosylmethionine-dependent methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | S-adenosylmethionine-dependent methyltransferase activity
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  transferase activity, transferring one-carbon groups
   |__methyltransferase activity
       |__S-adenosylmethionine-dependent methyltransferase activity  127 rec.
           |__(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
           |__(RS)-norcoclaurine 6-O-methyltransferase activity
           |__(S)-coclaurine-N-methyltransferase activity
           |__(S)-scoulerine 9-O-methyltransferase activity
           |__(S)-tetrahydroprotoberberine N-methyltransferase activity
           |__2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity
           |__2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity
           |__3'-demethylstaurosporine O-methyltransferase activity
           |__3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity
           |__3,5-dichloro-THPH methyl transferase activity
           |__3,7-dimethylquercitin 4'-O-methyltransferase activity
           |__3-demethylubiquinol 3-O-methyltransferase activity 1 rec.
           |__3-demethylubiquinone 3-O-methyltransferase activity
           |__3-hydroxyanthranilate 4-C-methyltransferase activity
           |__3-methylquercitin 7-O-methyltransferase activity
           |__4-vinylphenol methyltransferase activity
           |__5-hydroxyfuranocoumarin 5-O-methyltransferase activity
           |__6-hydroxymellein O-methyltransferase activity
           |__6-O-methylnorlaudanosoline 5'-O-methyltransferase activity
           |__8-hydroxyfuranocoumarin 8-O-methyltransferase activity
           |__8-hydroxyquercitin 8-O-methyltransferase activity
           |__10-hydroxydihydrosanguinarine 10-O-methyltransferase activity
           |__11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity
           |__12-hydroxydihydrochelirubine 12-O-methyltransferase activity
           |__16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity
           |__24-methylenesterol C-methyltransferase activity
           |__[cytochrome c]-methionine S-methyltransferase activity
           |__[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity
           |__acetylserotonin O-methyltransferase activity
           |__amine N-methyltransferase activity
           |__anthranilate N-methyltransferase activity
           |__apigenin 4'-O-methyltransferase activity
           |__arginine N-methyltransferase activity 13 rec.
           |   |__protein-arginine N-methyltransferase activity(+) 13 rec.
           |__arsenite methyltransferase activity
           |__caffeoyl-CoA O-methyltransferase activity
           |__carnosine N-methyltransferase activity 1 rec.
           |__catechol O-methyltransferase activity
           |__chlorophenol O-methyltransferase activity
           |__columbamine O-methyltransferase activity
           |__cycloartenol 24-C-methyltransferase activity
           |__cyclopropane-fatty-acyl-phospholipid synthase activity
           |__demethylmacrocin O-methyltransferase activity
           |__dimethylglycine N-methyltransferase activity
           |__diphthine methyl ester synthase activity 1 rec.
           |__diphthine synthase activity
           |__DNA (cytosine-5-)-methyltransferase activity 1 rec.
           |   |__ATP-dependent DNA (cytosine-5-)-methyltransferase activity
           |   |__DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
           |   |__DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates
           |   |__DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates
           |__farnesoic acid O-methyltransferase activity 1 rec.
           |__fatty acid O-methyltransferase activity
           |__flavone 3'-O-methyltransferase activity
           |__glucuronoxylan 4-O-methyltransferase activity
           |__glycine N-methyltransferase activity 1 rec.
           |__guanidinoacetate N-methyltransferase activity
           |__histamine N-methyltransferase activity
           |__indolepyruvate C-methyltransferase activity
           |__inositol 1-methyltransferase activity
           |__inositol 3-methyltransferase activity
           |__inositol 4-methyltransferase activity
           |__iodophenol O-methyltransferase activity
           |__isobutyraldoxime O-methyltransferase activity
           |__isoflavone 4'-O-methyltransferase activity
           |__isoflavone 7-O-methyltransferase activity
           |__isoliquiritigenin 2'-O-methyltransferase activity
           |__isoorientin 3'-O-methyltransferase activity
           |__kaempferol 4'-O-methyltransferase activity
           |__L-histidine N(alpha)-methyltransferase activity
           |__laricitrin 5'-O-methyltransferase activity
           |__licodione 2'-O-methyltransferase activity
           |__lipid A phosphate methyltransferase activity
           |__loganate O-methyltransferase activity
           |__lysine N-methyltransferase activity 52 rec.
           |   |__protein-lysine N-methyltransferase activity(+) 52 rec.
           |__macrocin O-methyltransferase activity
           |__magnesium protoporphyrin IX methyltransferase activity
           |__methionine S-methyltransferase activity
           |__methyl jasmonate methylesterase activity
           |__methylene-fatty-acyl-phospholipid synthase activity
           |__methylquercetagetin 6-O-methyltransferase activity
           |__mRNA methyltransferase activity 6 rec.
           |   |__internal mRNA (guanine-N7-)-methyltransferase activity
           |   |__mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
           |   |__mRNA (adenine-N1-)-methyltransferase activity
           |   |__mRNA (cytidine-5-)-methyltransferase activity 1 rec.
           |   |__mRNA 5'-cap (guanine-N7-)-methyltransferase activity 1 rec.
           |   |__mRNA m(6)A methyltransferase activity 3 rec.
           |__myricetin 3'-O-methyltransferase activity
           |__N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity
           |__N-terminal protein N-methyltransferase activity 1 rec.
           |__nicotinamide N-methyltransferase activity
           |__nicotinate N-methyltransferase activity
           |__O-demethylpuromycin O-methyltransferase activity
           |__phenol O-methyltransferase activity
           |__phenylethanolamine N-methyltransferase activity
           |__phosphatidyl-N-methylethanolamine N-methyltransferase activity
           |__phosphatidylethanolamine N-methyltransferase activity
           |__phosphoethanolamine N-methyltransferase activity
           |__polyprenyldihydroxybenzoate methyltransferase activity 1 rec.
           |__polysaccharide O-methyltransferase activity
           |__precorrin-2 C20-methyltransferase activity
           |__precorrin-3B C17-methyltransferase activity
           |__precorrin-4 C11-methyltransferase activity
           |__precorrin-6Y C5,15-methyltransferase (decarboxylating) activity
           |__protein C-terminal leucine carboxyl O-methyltransferase activity 1 rec.
           |__protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity 1 rec.
           |__protein-arginine C-methyltransferase activity
           |__protein-cysteine methyltransferase activity 1 rec.
           |__protein-glutamate O-methyltransferase activity
           |__protein-glutamine N-methyltransferase activity 5 rec.
           |   |__histone H2AQ104 methyltransferase activity 2 rec.
           |   |__peptide chain release factor N(5)-glutamine methyltransferase activity 1 rec.
           |__protein-L-histidine N-pros-methyltransferase activity 1 rec.
           |__protein-L-histidine N-tele-methyltransferase activity 2 rec.
           |__protein-L-isoaspartate (D-aspartate) O-methyltransferase activity 1 rec.
           |__putrescine N-methyltransferase activity
           |__pyridine N-methyltransferase activity
           |__quercetin 3-O-methyltransferase activity
           |__RNA 5'-gamma-phosphate methyltransferase activity
           |__RNA cap trimethylguanosine synthase activity 1 rec.
           |__rRNA methyltransferase activity 21 rec.
           |   |__rRNA (adenine) methyltransferase activity(+) 6 rec.
           |   |__rRNA (cytosine) methyltransferase activity(+) 6 rec.
           |   |__rRNA (guanine) methyltransferase activity(+) 3 rec.
           |   |__rRNA (pseudouridine) methyltransferase activity(+) 1 rec.
           |   |__rRNA (uridine) methyltransferase activity(+) 4 rec.
           |__S-adenosylmethionine-homocysteine S-methyltransferase activity 2 rec.
           |__sarcosine N-methyltransferase activity
           |__site-specific DNA-methyltransferase (adenine-specific) activity
           |__site-specific DNA-methyltransferase (cytosine-N4-specific) activity
           |__sterol 24-C-methyltransferase activity
           |__tellurite methyltransferase activity
           |__tetrahydrocolumbamine 2-O-methyltransferase activity
           |__thioether S-methyltransferase activity
           |__thiol S-methyltransferase activity
           |__thiopurine S-methyltransferase activity
           |__trans-aconitate 2-methyltransferase activity
           |__trans-aconitate 3-methyltransferase activity
           |__tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity
           |__tRNA (adenine) methyltransferase activity 4 rec.
           |   |__tRNA (adenine(9)-N1)-methyltransferase activity 1 rec.
           |   |__tRNA (adenine(22)-N1)-methyltransferase activity
           |   |__tRNA (adenine(37)-C2)-methyltransferase activity
           |   |__tRNA (adenine(57)-N1)/(adenine(58)-N1)-methyltransferase activity
           |   |__tRNA (adenine(58)-N1)-methyltransferase activity 1 rec.
           |   |__tRNA (cytidine(4)/adenine(4)-2'-O-ribose)-methyltransferase activity
           |   |__tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity 2 rec.
           |   |__tRNA(Val) (adenine(37)-N6)-methyltransferase activity
           |__tRNA (cytidine) methyltransferase activity 7 rec.
           |   |__tRNA (cytidine(4)/adenine(4)-2'-O-ribose)-methyltransferase activity
           |   |__tRNA (cytidine(32)-2'-O-ribose)-methyltransferase activity 1 rec.
           |   |__tRNA (cytidine(32)/uridine(32)-2'-O-ribose)-methyltransferase activity
           |   |__tRNA (cytidine(34)-2'-O-ribose)-methyltransferase activity 2 rec.
           |   |__tRNA (cytidine(56)-2'-O-ribose)-methyltransferase activity
           |   |__tRNA (cytidine-N3)-methyltransferase activity 1 rec.
           |   |__tRNA (cytidine-N5)-methyltransferase activity 3 rec.
           |__tRNA (guanine) methyltransferase activity 10 rec.
           |   |__tRNA (guanine(6)-N2)-methyltransferase activity
           |   |__tRNA (guanine(7)-N2)-methyltransferase activity
           |   |__tRNA (guanine(10)-N2)-dimethyltransferase activity
           |   |__tRNA (guanine(10)-N2)-methyltransferase activity 1 rec.
           |   |__tRNA (guanine(18)-2'-O-ribose)-methyltransferase activity 1 rec.
           |   |__tRNA (guanine(26)-N2)-dimethyltransferase activity 1 rec.
           |   |__tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity
           |   |__tRNA (guanine(27)-N2)-dimethyltransferase activity
           |   |__tRNA (guanine(37)-N1)-methyltransferase activity 1 rec.
           |   |__tRNA (guanine(46)-N7)-methyltransferase activity 2 rec.
           |   |__tRNA (guanosine(9)-N1)-methyltransferase activity 2 rec.
           |   |__tRNA (guanosine(34)-2'-O-ribose)-methyltransferase activity 2 rec.
           |__tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent 1 rec.
           |__tryptophan 2-C-methyltransferase activity
           |__tyramine N-methyltransferase activity
           |__uroporphyrin-III C-methyltransferase activity
           |__vitexin 2''-O-rhamnoside 7-O-methyltransferase activity
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Synonyms
  • "S-adenosyl methionine-dependent methyltransferase activity" EXACT
    "SAM-dependent methyltransferase activity" EXACT
Secondary IDs
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