FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term holo-[acyl-carrier-protein] synthase activity ID (Ontology) GO:0008897 (Gene Ontology)
Definition Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.[ EC:2 PubMed:10320345 PubMed:11867633 PubMed:8939709 ]
Also Known As"4'-phosphopantetheinyltransferase activity" ; "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" ; "phosphopantetheinyltransferase activity"
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 holo-[acyl-carrier-protein] synthase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | holo-[acyl-carrier-protein] synthase activity
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  transferase activity, transferring phosphorus-containing groups
   |__phosphotransferase activity, for other substituted phosphate groups
       |__holo-[acyl-carrier-protein] synthase activity  1 rec.
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Is a phosphotransferase activity, for other substituted phosphate groups
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Synonyms
  • "4'-phosphopantetheinyl transferase activity" RELATED[ EC:2 ]
    "4'-phosphopantetheinyltransferase activity" EXACT
    "AcpS" RELATED[ EC:2 ]
    "ACPS activity" RELATED[ EC:2 ]
    "acyl carrier protein holoprotein (holo-ACP) synthetase activity" RELATED[ EC:2 ]
    "acyl carrier protein synthase activity" RELATED[ EC:2 ]
    "acyl carrier protein synthetase activity" RELATED[ EC:2 ]
    "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" EXACT
    "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" RELATED[ EC:2 ]
    "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" RELATED[ EC:2 ]
    "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity" RELATED
    "CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity" RELATED[ EC:2 ]
    "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity" RELATED[ EC:2 ]
    "holo-[peptidyl-carrier protein] synthase activity" NARROW
    "holo-ACP synthase activity" RELATED[ EC:2 ]
    "holo-ACP synthetase activity" RELATED[ EC:2 ]
    "holo-acyl-carrier-protein synthase activity" RELATED[ EC:2 ]
    "holosynthase activity" RELATED[ EC:2 ]
    "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" NARROW[ EC:2 ]
    "P-pant transferase activity" RELATED[ EC:2 ]
    "phosphopantetheinyl transferase" RELATED
    "phosphopantetheinyltransferase activity" EXACT
    "PPTase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.7.8.7
MetaCyc:HOLO-ACP-SYNTH-RXN
Reactome:R-HSA-199202 "Phosphopantetheine conjugation of the ACP domain of FAS"
RHEA:12068
RHEA:53968