FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
Help Close All Open All
General Information
Term fatty acid elongase activity ID (Ontology) GO:0009922 (Gene Ontology)
Definition Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.[ PubMed:16564093 PubMed:19763486 ]
Also Known As "elongation of very long chain fatty acids activity" ; "ELOVL" ; "very-long-chain 3-ketoacyl-CoA synthase" (for all, see Synonyms field below)
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      20
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 fatty acid elongase activity (all annotations which use CV term, excluding "NOT" statements)       1     20
     enables | fatty acid elongase activity       --      20
Spanning Tree (Parents/Children)
Only view relationship: 
  acyltransferase activity
   |__acyltransferase activity, transferring groups other than amino-acyl groups
       |__fatty acid elongase activity  21 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a acyltransferase activity, transferring groups other than amino-acyl groups
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "condensing enzyme" BROAD
    "elongation of very long chain fatty acids activity" EXACT
    "ELOVL" EXACT
    "very-long-chain 3-ketoacyl-CoA synthase" EXACT
    "very-long-chain 3-oxoacyl-CoA synthase" EXACT
    "very-long-chain beta-ketoacyl-CoA synthase" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
EC:2.3.1.199
MetaCyc:RXN-7697
Reactome:R-HSA-2046083 "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA"
Reactome:R-HSA-2046088 "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA"
Reactome:R-HSA-2046090 "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA"
Reactome:R-HSA-2046094 "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA"
Reactome:R-HSA-2046095 "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA"
Reactome:R-HSA-2046100 "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA"
Reactome:R-HSA-548800 "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA"
Reactome:R-HSA-548814 "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA"
Reactome:R-HSA-548815 "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA"
Reactome:R-HSA-548830 "ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA"
RHEA:32727