FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term pseudouridine synthase activity ID (Ontology) GO:0009982 (Gene Ontology)
Definition Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       9
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 pseudouridine synthase activity (all annotations which use CV term, excluding "NOT" statements)       2      9
     enables | pseudouridine synthase activity       --       9
Spanning Tree (Parents/Children)
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  isomerase activity
   |__intramolecular transferase activity
       |__pseudouridine synthase activity  11 rec.
           |__rRNA pseudouridine synthase activity
           |   |__16S rRNA pseudouridine(516) synthase activity
           |   |__21S rRNA pseudouridine(2819) synthase activity
           |   |__23S rRNA pseudouridine(746) synthase activity
           |   |__23S rRNA pseudouridine(955/2504/2580) synthase activity
           |   |__23S rRNA pseudouridine(1911/1915/1917) synthase activity
           |   |__23S rRNA pseudouridine(2457) synthase activity
           |   |__23S rRNA pseudouridine(2604) synthase activity
           |   |__23S rRNA pseudouridine(2605) synthase activity
           |__snRNA pseudouridine synthase activity
           |__tRNA pseudouridine synthase activity 6 rec.
               |__mitochondrial tRNA pseudouridine(27/28) synthase activity 1 rec.
               |__tRNA pseudouridine(13) synthase activity 1 rec.
               |__tRNA pseudouridine(31) synthase activity
               |__tRNA pseudouridine(32) synthase activity
               |__tRNA pseudouridine(38-40) synthase activity
               |__tRNA pseudouridine(38/39) synthase activity 1 rec.
               |__tRNA pseudouridine(55) synthase activity 1 rec.
               |__tRNA pseudouridine(65) synthase activity
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Is a intramolecular transferase activity
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Reactome:R-HSA-6782381 "PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs"
Reactome:R-HSA-6786583 "PUS7 transforms uridine to pseudouridine in tRNAs"
Reactome:R-HSA-6787566 "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser)"
Reactome:R-HSA-6790905 "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA"
Reactome:R-HSA-8870289 "PUS3 transforms uridine-39 to pseudouridine-39 in tRNA"
RHEA:48348