FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term heparan sulfate N-sulfotransferase activity ID (Ontology) GO:0015016 (Gene Ontology)
Definition Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-[heparan sulfate](n) = adenosine 3',5'-bisphosphate + 2 H+ + N-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n).[ EC:2 ]
Also Known As"[heparan sulfate]-glucosamine N-sulfotransferase activity" ; "[heparan sulphate]-glucosamine N-sulphotransferase activity" ; "desulfoheparin sulfotransferase activity" (for all, see Synonyms field below)
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 heparan sulfate N-sulfotransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | heparan sulfate N-sulfotransferase activity
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  proteoglycan sulfotransferase activity
   |__heparan sulfate sulfotransferase activity
       |__heparan sulfate N-sulfotransferase activity  1 rec.
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Is a heparan sulfate sulfotransferase activity
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Synonyms
  • "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity" RELATED[ EC:2 ]
    "3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity" RELATED[ EC:2 ]
    "3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity" RELATED[ EC:2 ]
    "3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity" RELATED[ EC:2 ]
    "[heparan sulfate]-glucosamine N-sulfotransferase activity" EXACT
    "[heparan sulphate]-glucosamine N-sulphotransferase activity" EXACT
    "desulfoheparin sulfotransferase activity" EXACT
    "glucosaminyl N-deacetylase/N-sulfotransferase activity" RELATED[ EC:2 ]
    "heparan sulfate 2-N-sulfotransferase activity" RELATED[ EC:2 ]
    "heparan sulfate N-deacetylase/N-sulfotransferase activity" RELATED[ EC:2 ]
    "heparin N-deacetylase/N-sulfotransferase activity" RELATED
    "heparin N-deacetylase/N-sulphotransferase activity" RELATED
    "heparin N-sulfotransferase activity" RELATED[ EC:2 ]
    "heparin-glucosamine N-sulfotransferase activity" EXACT
    "heparitin N-sulfotransferase activity" EXACT
    "heparitin N-sulphotransferase activity" EXACT
    "heparitin sulfotransferase activity" EXACT
    "N-desulfoheparin sulfotransferase activity" RELATED[ EC:2 ]
    "N-heparan sulfate sulfotransferase activity" RELATED[ EC:2 ]
    "N-HSST activity" RELATED[ EC:2 ]
    "PAPS:DSH sulfotransferase activity" RELATED[ EC:2 ]
    "PAPS:N-desulfoheparin sulfotransferase activity" RELATED[ EC:2 ]
Secondary IDs
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EC:2.8.2.8
MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN
Reactome:R-HSA-2022860 "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)"
RHEA:21980