FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term protein-disulfide reductase activity ID (Ontology) GO:0015035 (Gene Ontology)
Definition Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.[ PubMed:18331844 ]
Also Known As"peptide disulfide oxidoreductase activity" ; "peptide disulphide oxidoreductase activity" ; "protein disulfide oxidoreductase activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 protein-disulfide reductase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | protein-disulfide reductase activity       --
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catalytic activity
 |__catalytic activity, acting on a protein__________________
oxidoreductase activity, acting on a sulfur group of donors  |
 |__disulfide oxidoreductase activity________________________|
                                                             protein-disulfide reductase activity  28 rec.
                                                              |__flavin-dependent sulfhydryl oxidase activity 6 rec.
                                                              |__protein-disulfide reductase (glutathione) activity
                                                              |__protein-disulfide reductase [NAD(P)H] activity 7 rec.
                                                                  |__thioredoxin-disulfide reductase (NADPH) activity 5 rec.
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Is a disulfide oxidoreductase activity
catalytic activity, acting on a protein
Part of
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Synonyms
  • "haem lyase disulphide oxidoreductase activity" NARROW
    "heme lyase disulfide oxidoreductase activity" NARROW
    "peptide disulfide oxidoreductase activity" EXACT
    "peptide disulphide oxidoreductase activity" EXACT
    "protein disulfide oxidoreductase activity" EXACT
    "protein disulfide-oxidoreductase activity" EXACT
    "protein disulphide oxidoreductase activity" EXACT
Secondary IDs
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Reactome:R-HSA-1307802 "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds"
Reactome:R-HSA-264997 "P4HB mediates disulfide bond formation in Proinsulin"
Reactome:R-HSA-3299753 "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1"
Reactome:R-HSA-9817575 "ERO1B oxidizes P4HB"