FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term channel activity ID (Ontology) GO:0015267 (Gene Ontology)
Definition Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.[ ISBN:0815340729 ]
Also Known As"channel/pore class transporter activity" ; "nonselective channel activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 channel activity (all annotations which use CV term, excluding "NOT" statements)
     enables | channel activity       --
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  transmembrane transporter activity
   |__passive transmembrane transporter activity
       |__channel activity  511 rec.
           |__ammonium channel activity 3 rec.
           |__bicarbonate channel activity
           |__borate channel activity
           |__channel-forming ionophore activity
           |__gated channel activity 370 rec.
           |   |__G-protein gated monoatomic ion channel activity(+)
           |   |__ligand-gated channel activity(+) 312 rec.
           |   |__mechanosensitive monoatomic ion channel activity(+) 17 rec.
           |   |__osmolarity-sensing monoatomic cation channel activity
           |   |__temperature-gated ion channel activity(+) 1 rec.
           |   |__voltage-gated channel activity(+) 53 rec.
           |__glycerol channel activity
           |__hydrogen peroxide channel activity
           |__methylammonium channel activity
           |__monoatomic ion channel activity 467 rec.
           |   |__ligand-gated monoatomic ion channel activity(+) 297 rec.
           |   |__light-activated monoatomic ion channel activity(+)
           |   |__mechanosensitive monoatomic ion channel activity(+) 17 rec.
           |   |__monoatomic anion channel activity(+) 43 rec.
           |   |__monoatomic cation channel activity(+) 229 rec.
           |   |__temperature-gated ion channel activity(+) 1 rec.
           |   |__voltage-gated monoatomic ion channel activity(+) 52 rec.
           |__narrow pore channel activity 14 rec.
           |   |__leak channel activity(+) 14 rec.
           |   |__narrow pore, gated channel activity
           |__urea channel activity
           |__water channel activity 11 rec.
           |__wide pore channel activity 12 rec.
               |__gap junction channel activity(+) 9 rec.
               |__gap junction hemi-channel activity 1 rec.
               |__porin activity(+) 3 rec.
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Is a passive transmembrane transporter activity
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Synonyms
  • "alpha-type channel activity" RELATED
    "channel-forming toxin activity" RELATED
    "channel/pore class transporter activity" EXACT
    "nonselective channel activity" EXACT
    "pore activity" BROAD
    "pore class transporter activity" RELATED
    "substrate-specific channel activity" RELATED
Secondary IDs
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Reactome:R-HSA-3779381 "H2O2 diffuses from the mitochondrial matrix to the cytosol"
Reactome:R-HSA-8953430 "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix"
Reactome:R-HSA-9857649 "p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports ATP from the cytosol to the extracellular region"
Reactome:R-HSA-9857682 "p-S373-GJA1:p-S-ITGA5:ITGB1 (p-S373-Connexin-43:p-S-Integrin alpha5:Integrin beta1) transports prostaglandin E2 (PGE2) from the cytosol to the extracellular region"
Reactome:R-HSA-9905999 "Pannexin1 (PANX1) channel in a complex with P2RX7 transports ATP from the cytosol to the extracellular region"
TC:1