FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term secondary active transmembrane transporter activity ID (Ontology) GO:0015291 (Gene Ontology)
Definition Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters.[ ISBN:0198506732 ISBN:0815340729 PubMed:10839820 ]
Also Known As "coupled carrier" ; "electrochemical potential-driven transporter activity" ; "porter activity" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       8
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 secondary active transmembrane transporter activity (all annotations which use CV term, excluding "NOT" statements)       8
     enables | secondary active transmembrane transporter activity       8
Spanning Tree (Parents/Children)
Only view relationship: 
  transmembrane transporter activity
   |__active transmembrane transporter activity
       |__secondary active transmembrane transporter activity  132 rec.
           |__antimonite secondary active transmembrane transporter activity
           |__antiporter activity 48 rec.
           |   |__(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
           |   |__acetyl-CoA:CoA antiporter activity
           |   |__acetylcholine:proton antiporter activity
           |   |__acridine:proton antiporter activity
           |   |__agmatine:putrescine antiporter activity
           |   |__amino acid:monoatomic cation antiporter activity(+) 3 rec.
           |   |__arginine:agmatine antiporter activity
           |   |__arginine:ornithine antiporter activity
           |   |__aspartate:alanine antiporter activity
           |   |__ATP:ADP antiporter activity 2 rec.
           |   |__azole:proton antiporter activity(+)
           |   |__benomyl:proton antiporter activity
           |   |__bicarbonate:monoatomic anion antiporter activity(+)
           |   |__broad specificity neutral L-amino acid:basic L-amino acid antiporter activity
           |   |__carnitine:O-acyl-L-carnitine antiporter activity
           |   |__citrate:2-oxoglutarate antiporter activity
           |   |__citrate:succinate antiporter activity
           |   |__cycloheximide:proton antiporter activity
           |   |__cystine:glutamate antiporter activity
           |   |__folate:monoatomic anion antiporter activity
           |   |__glutamate:gamma-aminobutyric acid antiporter activity
           |   |__GTP:GDP antiporter activity
           |   |__L-aspartate:fumarate antiporter activity
           |   |__L-histidine:histamine antiporter activity
           |   |__L-lysine:L-arginine antiporter activity
           |   |__lysine:cadaverine antiporter activity
           |   |__metal cation:monoatomic cation antiporter activity(+) 23 rec.
           |   |__monoamine:proton antiporter activity 1 rec.
           |   |__orotate:monoatomic anion antiporter activity
           |   |__oxoglutarate:malate antiporter activity
           |   |__polyamine:proton antiporter activity
           |   |__polyspecific organic cation:proton antiporter activity
           |   |__putrescine:ornithine antiporter activity
           |   |__S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity
           |   |__solute:inorganic anion antiporter activity(+) 10 rec.
           |   |__succinate:fumarate antiporter activity
           |   |__tartrate:succinate antiporter activity
           |   |__tetracycline:proton antiporter activity
           |   |__tyrosine:tyramine antiporter activity
           |   |__urate:monoatomic anion antiporter activity
           |__arsenite secondary active transmembrane transporter activity
           |__high-affinity secondary active nitrite transmembrane transporter activity
           |   |__nitrate efflux transmembrane transporter activity
           |   |__nitrate:proton symporter activity
           |__neutral L-amino acid secondary active transmembrane transporter activity
           |   |__L-methionine secondary active transmembrane transporter activity
           |__nitrite efflux transmembrane transporter activity
           |__nucleoside transmembrane transporter activity, against a concentration gradient
           |__phosphate transmembrane transporter activity 14 rec.
           |   |__ATPase-coupled phosphate ion transmembrane transporter activity
           |   |__dicarboxylate:phosphate antiporter activity
           |   |__high-affinity phosphate transmembrane transporter activity
           |   |__low-affinity phosphate transmembrane transporter activity
           |   |__organophosphate:phosphate antiporter activity(+) 3 rec.
           |   |__phosphate ion uniporter activity
           |   |__phosphate:proton symporter activity
           |   |__sodium:phosphate symporter activity(+) 3 rec.
           |__proton motive force dependent protein transmembrane transporter activity
           |__proton-dependent oligopeptide secondary active transmembrane transporter activity 2 rec.
           |__secondary active cyanate transmembrane transporter activity
           |__secondary active monocarboxylate transmembrane transporter activity 6 rec.
           |   |__2-keto-3-deoxygluconate:proton symporter activity
           |   |__acetate:monoatomic cation symporter activity(+)
           |   |__bile acid:sodium symporter activity
           |   |__D-galactonate:proton symporter activity
           |   |__gamma-aminobutyric acid:proton antiporter activity 2 rec.
           |   |__gamma-aminobutyric acid:proton symporter activity 1 rec.
           |   |__gamma-aminobutyric acid:sodium:chloride symporter activity 1 rec.
           |   |__glutamate:gamma-aminobutyric acid antiporter activity
           |   |__lactate:proton symporter activity 1 rec.
           |   |__orotate:monoatomic anion antiporter activity
           |   |__phenyl propionate uniporter activity
           |   |__phosphoenolpyruvate:phosphate antiporter activity
           |   |__pyruvate secondary active transmembrane transporter activity 1 rec.
           |   |__shikimate:proton symporter activity
           |__secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
           |__secondary active sulfate transmembrane transporter activity
           |   |__high-affinity sulfate transmembrane transporter activity
           |   |__sodium:sulfate symporter activity
           |   |__sulfate:bicarbonate antiporter activity
           |   |__sulfate:chloride antiporter activity
           |   |__sulfate:proton symporter activity(+)
           |__symporter activity 65 rec.
           |   |__solute:monoatomic cation symporter activity(+) 54 rec.
           |__thyroid hormone transmembrane transporter activity
           |__tricarboxylate secondary active transmembrane transporter activity 1 rec.
           |   |__citrate secondary active transmembrane transporter activity(+) 1 rec.
           |__uniporter activity 2 rec.
               |__dipeptide uniporter activity
               |__hexose uniporter activity(+)
               |__membrane potential driven uniporter activity(+)
               |__phenyl propionate uniporter activity
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Is a active transmembrane transporter activity
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Synonyms
  • "active transporter" BROAD
    "coupled carrier" EXACT
    "electrochemical potential-driven transporter activity" EXACT
    "energizer of outer membrane receptor-mediated transport activity" NARROW
    "galactose/glucose (methylgalactoside) porter activity" RELATED
    "heavy metal ion porter activity" NARROW
    "ion-gradient-driven energizer activity" NARROW
    "multidrug endosomal transmembrane transporter activity" NARROW
    "nitrite/nitrate porter activity" NARROW
    "porter activity" EXACT
    "porters" EXACT
    "secondary carrier-type facilitators" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-549241 "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol"
Reactome:R-HSA-561059 "OAT2 and OAT4 mediate transport of sulphate conjugates"
Reactome:R-HSA-879562 "SLCO2B1 has a narrow substrate specificity"
Reactome:R-HSA-879584 "SLCO3A1 isoform 1 has a broad substrate specificity"
Reactome:R-HSA-879594 "SLCO4C1 mediates the transport of digoxin"
Reactome:R-HSA-9661397 "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)"
Reactome:R-HSA-9661446 "BMG, BDG translocates from ER lumen to cytosol"
Reactome:R-HSA-9661723 "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)"
Reactome:R-HSA-9661799 "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)"
Reactome:R-HSA-9749583 "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes"
Reactome:R-HSA-9749607 "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells"
Reactome:R-HSA-9757010 "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol"
TC:2.A