FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term secondary active transmembrane transporter activity ID (Ontology) GO:0015291 (Gene Ontology)
Definition Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters.[ ISBN:0198506732 ISBN:0815340729 PubMed:10839820 ]
Also Known As "coupled carrier" ; "electrochemical potential-driven transporter activity" ; "porter activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 secondary active transmembrane transporter activity (all annotations which use CV term, excluding "NOT" statements)
     enables | secondary active transmembrane transporter activity
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  transmembrane transporter activity
   |__active transmembrane transporter activity
       |__secondary active transmembrane transporter activity  143 rec.
           |__antimonite secondary active transmembrane transporter activity
           |__antiporter activity 55 rec.
           |   |__(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
           |   |__acetyl-CoA:CoA antiporter activity
           |   |__acetylcholine:proton antiporter activity 1 rec.
           |   |__acridine:proton antiporter activity
           |   |__agmatine:putrescine antiporter activity
           |   |__amino acid:monoatomic cation antiporter activity(+) 5 rec.
           |   |__arginine:agmatine antiporter activity
           |   |__arginine:ornithine antiporter activity
           |   |__aspartate:alanine antiporter activity
           |   |__ATP:ADP antiporter activity 2 rec.
           |   |__azole:proton antiporter activity(+)
           |   |__benomyl:proton antiporter activity
           |   |__bicarbonate:monoatomic anion antiporter activity(+) 1 rec.
           |   |__broad specificity neutral L-amino acid:basic L-amino acid antiporter activity
           |   |__carnitine:O-acyl-L-carnitine antiporter activity
           |   |__citrate:2-oxoglutarate antiporter activity
           |   |__citrate:succinate antiporter activity
           |   |__cycloheximide:proton antiporter activity
           |   |__cystine:glutamate antiporter activity
           |   |__folate:monoatomic anion antiporter activity
           |   |__glutamate:gamma-aminobutyric acid antiporter activity
           |   |__GTP:GDP antiporter activity
           |   |__L-aspartate:fumarate antiporter activity
           |   |__L-histidine:histamine antiporter activity
           |   |__L-lysine:L-arginine antiporter activity
           |   |__lysine:cadaverine antiporter activity
           |   |__metal cation:monoatomic cation antiporter activity(+) 23 rec.
           |   |__monoamine:proton antiporter activity 3 rec.
           |   |__orotate:monoatomic anion antiporter activity
           |   |__oxoglutarate:malate antiporter activity
           |   |__polyamine:proton antiporter activity
           |   |__polyspecific organic cation:proton antiporter activity
           |   |__putrescine:ornithine antiporter activity
           |   |__S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity
           |   |__solute:inorganic anion antiporter activity(+) 10 rec.
           |   |__succinate:fumarate antiporter activity
           |   |__tartrate:succinate antiporter activity
           |   |__tetracycline:proton antiporter activity
           |   |__tyrosine:tyramine antiporter activity
           |   |__urate:monoatomic anion antiporter activity
           |__arsenite secondary active transmembrane transporter activity
           |__high-affinity secondary active nitrite transmembrane transporter activity
           |   |__nitrate efflux transmembrane transporter activity
           |   |__nitrate:proton symporter activity
           |__neutral L-amino acid secondary active transmembrane transporter activity
           |   |__L-methionine secondary active transmembrane transporter activity
           |__nitrite efflux transmembrane transporter activity
           |__nucleoside transmembrane transporter activity, against a concentration gradient
           |__phosphate transmembrane transporter activity 17 rec.
           |   |__ATPase-coupled phosphate ion transmembrane transporter activity
           |   |__dicarboxylate:phosphate antiporter activity
           |   |__high-affinity phosphate transmembrane transporter activity
           |   |__low-affinity phosphate transmembrane transporter activity
           |   |__organophosphate:phosphate antiporter activity(+) 3 rec.
           |   |__phosphate ion uniporter activity
           |   |__phosphate:proton symporter activity
           |   |__sodium:phosphate symporter activity(+) 3 rec.
           |__proton motive force dependent protein transmembrane transporter activity
           |__proton-dependent oligopeptide secondary active transmembrane transporter activity 2 rec.
           |__secondary active cyanate transmembrane transporter activity
           |__secondary active monocarboxylate transmembrane transporter activity 6 rec.
           |   |__2-keto-3-deoxygluconate:proton symporter activity
           |   |__acetate:monoatomic cation symporter activity(+)
           |   |__bile acid:sodium symporter activity
           |   |__D-galactonate:proton symporter activity
           |   |__gamma-aminobutyric acid:proton antiporter activity 2 rec.
           |   |__gamma-aminobutyric acid:proton symporter activity 1 rec.
           |   |__gamma-aminobutyric acid:sodium:chloride symporter activity 1 rec.
           |   |__glutamate:gamma-aminobutyric acid antiporter activity
           |   |__lactate:proton symporter activity 1 rec.
           |   |__orotate:monoatomic anion antiporter activity
           |   |__phenyl propionate uniporter activity
           |   |__phosphoenolpyruvate:phosphate antiporter activity
           |   |__pyruvate secondary active transmembrane transporter activity 1 rec.
           |   |__shikimate:proton symporter activity
           |__secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
           |__secondary active sulfate transmembrane transporter activity
           |   |__high-affinity sulfate transmembrane transporter activity
           |   |__sodium:sulfate symporter activity
           |   |__sulfate:bicarbonate antiporter activity
           |   |__sulfate:chloride antiporter activity
           |   |__sulfate:proton symporter activity(+)
           |__symporter activity 67 rec.
           |   |__solute:monoatomic cation symporter activity(+) 56 rec.
           |__thyroid hormone transmembrane transporter activity
           |__tricarboxylate secondary active transmembrane transporter activity 1 rec.
           |   |__citrate secondary active transmembrane transporter activity(+) 1 rec.
           |__uniporter activity 2 rec.
               |__dipeptide uniporter activity
               |__hexose uniporter activity(+)
               |__membrane potential driven uniporter activity(+)
               |__phenyl propionate uniporter activity
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Is a active transmembrane transporter activity
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Synonyms
  • "active transporter" BROAD
    "coupled carrier" EXACT
    "electrochemical potential-driven transporter activity" EXACT
    "energizer of outer membrane receptor-mediated transport activity" NARROW
    "galactose/glucose (methylgalactoside) porter activity" RELATED
    "heavy metal ion porter activity" NARROW
    "ion-gradient-driven energizer activity" NARROW
    "multidrug endosomal transmembrane transporter activity" NARROW
    "nitrite/nitrate porter activity" NARROW
    "porter activity" EXACT
    "porters" EXACT
    "secondary carrier-type facilitators" EXACT
Secondary IDs
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Reactome:R-HSA-549241 "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol"
Reactome:R-HSA-561059 "OAT2 and OAT4 mediate transport of sulphate conjugates"
Reactome:R-HSA-879562 "SLCO2B1 has a narrow substrate specificity"
Reactome:R-HSA-879584 "SLCO3A1 isoform 1 has a broad substrate specificity"
Reactome:R-HSA-879594 "SLCO4C1 mediates the transport of digoxin"
Reactome:R-HSA-9661397 "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)"
Reactome:R-HSA-9661446 "BMG, BDG translocates from ER lumen to cytosol"
Reactome:R-HSA-9661723 "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)"
Reactome:R-HSA-9661799 "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)"
Reactome:R-HSA-9749583 "SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes"
Reactome:R-HSA-9749607 "SLCO2B1-1 transports ASA- from extracellular region to cytosol of GI cells"
Reactome:R-HSA-9757010 "SLCO1B1,1B3,2B1-3 transport ATV from extracelluar region to cytosol"
TC:2.A