FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term sodium:proton antiporter activity ID (Ontology) GO:0015385 (Gene Ontology)
Definition Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
Also Known As"sodium/hydrogen antiporter activity" ; "sodium:hydrogen antiporter activity" ; "sodium:hydrogen exchange activity" (for all, see Synonyms field below)
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Gene Groups Genes
 sodium:proton antiporter activity (all annotations which use CV term, excluding "NOT" statements)
     enables | sodium:proton antiporter activity       --
 NOT | enables | sodium:proton antiporter activity       --
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Vocabulary search 
proton transmembrane transporter activity
 |__metal cation:proton antiporter activity_________
metal ion transmembrane transporter activity        |
 |__sodium ion transmembrane transporter activity___|
metal cation:monoatomic cation antiporter activity  |
 |__metal cation:proton antiporter activity_________|
                                                    sodium:proton antiporter activity  7 rec.
                                                     |__L-asparagine, sodium:proton antiporter activity
                                                     |__L-glutamine, sodium:proton antiporter activity
                                                     |__L-histidine, sodium:proton antiporter activity
                                                     |__neutral amino acid, sodium:proton antiporter activity
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Is a sodium ion transmembrane transporter activity
metal cation:proton antiporter activity
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Synonyms
  • "pH-dependent sodium:hydrogen antiporter activity" NARROW
    "pH-dependent sodium:proton antiporter activity" NARROW
    "sodium/hydrogen antiporter activity" EXACT
    "sodium:hydrogen antiporter activity" EXACT
    "sodium:hydrogen exchange activity" EXACT
    "sodium:hydrogen exchanger" EXACT
Secondary IDs
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MetaCyc:TRANS-RXN-129
Reactome:R-HSA-2872444 "SLC9B1/C2 exchange Na+ for H+"
Reactome:R-HSA-2872463 "SLC9C1 exchanges Na+ for H+"
Reactome:R-HSA-2889070 "SLC9B2 exchanges Na+ for H+"
Reactome:R-HSA-425965 "SLC9A9 exchanges Na+ for H+ across the late endosome membrane"
Reactome:R-HSA-425983 "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane"
Reactome:R-HSA-425994 "Na+/H+ exchanger transport (at cell membrane)"
Reactome:R-HSA-426015 "Na+/H+ exchanger transport (at trans-golgi membrane)"
Reactome:R-HSA-5661039 "Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane"
Reactome:R-HSA-5661086 "Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane"
RHEA:29251