FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
Help Close All Open All
General Information
Term sodium:proton antiporter activity ID (Ontology) GO:0015385 (Gene Ontology)
Definition Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
Also Known As "sodium/hydrogen antiporter activity" ; "sodium:hydrogen antiporter activity" ; "sodium:hydrogen exchange activity" (for all, see Synonyms field below)
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       6
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 sodium:proton antiporter activity (all annotations which use CV term, excluding "NOT" statements)       1      6
     enables | sodium:proton antiporter activity       --       6
 NOT | enables | sodium:proton antiporter activity       --       1
Spanning Tree (Parents/Children)
Only view relationship: 
proton transmembrane transporter activity
 |__metal cation:proton antiporter activity_________
metal ion transmembrane transporter activity        |
 |__sodium ion transmembrane transporter activity___|
metal cation:monoatomic cation antiporter activity  |
 |__metal cation:proton antiporter activity_________|
                                                    sodium:proton antiporter activity  7 rec.
                                                     |__L-asparagine, sodium:proton antiporter activity
                                                     |__L-glutamine, sodium:proton antiporter activity
                                                     |__L-histidine, sodium:proton antiporter activity
                                                     |__neutral amino acid, sodium:proton antiporter activity
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a sodium ion transmembrane transporter activity
metal cation:proton antiporter activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "pH-dependent sodium:hydrogen antiporter activity" NARROW
    "pH-dependent sodium:proton antiporter activity" NARROW
    "sodium/hydrogen antiporter activity" EXACT
    "sodium:hydrogen antiporter activity" EXACT
    "sodium:hydrogen exchange activity" EXACT
    "sodium:hydrogen exchanger" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
MetaCyc:TRANS-RXN-129
Reactome:R-HSA-2872444 "SLC9B1/C2 exchange Na+ for H+"
Reactome:R-HSA-2872463 "SLC9C1 exchanges Na+ for H+"
Reactome:R-HSA-2889070 "SLC9B2 exchanges Na+ for H+"
Reactome:R-HSA-425965 "SLC9A9 exchanges Na+ for H+ across the late endosome membrane"
Reactome:R-HSA-425983 "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane"
Reactome:R-HSA-425994 "Na+/H+ exchanger transport (at cell membrane)"
Reactome:R-HSA-426015 "Na+/H+ exchanger transport (at trans-golgi membrane)"
Reactome:R-HSA-5661039 "Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane"
Reactome:R-HSA-5661086 "Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane"
RHEA:29251