FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term NAD(P)H oxidase H2O2-forming activity ID (Ontology) GO:0016174 (Gene Ontology)
Definition Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + H2O2.[ EC:1 PubMed:10401672 PubMed:10601291 PubMed:11822874 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 NAD(P)H oxidase H2O2-forming activity (all annotations which use CV term, excluding "NOT" statements)
     enables | NAD(P)H oxidase H2O2-forming activity
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  oxidoreductase activity, acting on NAD(P)H
   |__oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
       |__NAD(P)H oxidase H2O2-forming activity  3 rec.
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Is a oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
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Synonyms
  • "dual oxidase activity" RELATED[ EC:1 ]
    "NAD(P)H oxidase activity" BROAD
    "NAD(P)H:oxygen oxidoreductase activity" RELATED[ EC:1 ]
    "NADPH oxidase" BROAD[ EC:1 ]
    "p138tox" RELATED[ EC:1 ]
    "ThOX activity" NARROW[ EC:1 ]
    "THOX2 activity" NARROW[ EC:1 ]
    "thyroid NADPH oxidase activity" NARROW
    "thyroid oxidase 2 activity" NARROW[ EC:1 ]
    "thyroid oxidase activity" NARROW[ EC:1 ]
Secondary IDs
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EC:1.6.3.1
Reactome:R-HSA-5693681 "DUOX1 reduces O2 to H2O2"
Reactome:R-HSA-9698758 "FLT3 ITD- and NOX4-dependent H2O2 production"
RHEA:11260
RHEA:11264