FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term superoxide-generating NAD(P)H oxidase activity ID (Ontology) GO:0016175 (Gene Ontology)
Definition Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-.[ PubMed:10806195 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 superoxide-generating NAD(P)H oxidase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | superoxide-generating NAD(P)H oxidase activity
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  oxidoreductase activity, acting on NAD(P)H
   |__oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
       |__superoxide-generating NAD(P)H oxidase activity  2 rec.
           |__superoxide-generating NADH oxidase activity
           |__superoxide-generating NADPH oxidase activity 2 rec.
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Is a oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
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Synonyms
  • "cytochrome B-245" RELATED
Secondary IDs
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Reactome:R-HSA-1222376 "NOX2 generates superoxide from oxygen"
Reactome:R-HSA-1236967 "Alkalization of the phagosomal lumen by NOX2"
Reactome:R-HSA-1497810 "Uncoupled eNOS favours the formation of superoxide"
Reactome:R-HSA-5218841 "NADPH oxidase 2 generates superoxide from oxygen"
Reactome:R-HSA-5668629 "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP"
Reactome:R-HSA-5668718 "NOX1 complex:RAC1:GTP generates superoxide from oxygen"
Reactome:R-HSA-5668731 "NOX3 complex:RAC1:GTP generates superoxide from oxygen"
Reactome:R-HSA-6789092 "NOX2 generates superoxide anion from oxygen"
Reactome:R-HSA-6807557 "NOX4, NOX5 reduce O2 to O2.-"
Reactome:R-HSA-9673797 "NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen"