FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term procollagen-proline 4-dioxygenase complex ID (Ontology) GO:0016222 (Gene Ontology)
Definition A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase.[ PubMed:14500733 PubMed:7753822 ]
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Genes (FBgn)GO_CELLULAR_COMPONENT
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 procollagen-proline 4-dioxygenase complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | procollagen-proline 4-dioxygenase complex
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endoplasmic reticulum
 |__endoplasmic reticulum protein-containing complex__
protein-containing complex                            |
 |__endoplasmic reticulum protein-containing complex__|
catalytic complex                                     |
 |__oxidoreductase complex____________________________|
                                                      procollagen-proline 4-dioxygenase complex  25 rec.
                                                       |__procollagen-proline 4-dioxygenase complex, alpha(I) type
                                                       |__procollagen-proline 4-dioxygenase complex, alpha(II) type
                                                       |__procollagen-proline 4-dioxygenase complex, alpha(III) type
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Is a endoplasmic reticulum protein-containing complex
oxidoreductase complex
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Synonyms
  • "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex" RELATED[ EC:1 ]
    "prolyl 4-hydroxylase complex" BROAD[ EC:1 ]
Secondary IDs
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