FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term acyl-CoA hydrolase activity ID (Ontology) GO:0016289 (Gene Ontology)
Definition Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+.
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 acyl-CoA hydrolase activity (all annotations which use CV term, excluding "NOT" statements)
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catalytic activity
 |__deacylase activity_____________________
hydrolase activity, acting on ester bonds  |
 |__thiolester hydrolase activity__________|
                                           acyl-CoA hydrolase activity  10 rec.
                                            |__(S)-methylmalonyl-CoA hydrolase activity
                                            |__1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity
                                            |__4-hydroxybenzoyl-CoA thioesterase activity
                                            |__acetoacetyl-CoA hydrolase activity
                                            |__acetyl-CoA hydrolase activity 4 rec.
                                            |__choloyl-CoA hydrolase activity
                                            |__fatty acyl-CoA hydrolase activity 9 rec.
                                            |   |__long-chain fatty acyl-CoA hydrolase activity 1 rec.
                                            |   |__medium-chain fatty acyl-CoA hydrolase activity
                                            |   |__short-chain fatty acyl-CoA hydrolase activity(+) 1 rec.
                                            |   |__very long-chain fatty acyl-CoA hydrolase activity
                                            |__hydroxymethylglutaryl-CoA hydrolase activity
                                            |__phenylacetyl-CoA hydrolase activity
                                            |__succinyl-CoA hydrolase activity
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Is a thiolester hydrolase activity
deacylase activity
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Synonyms
  • "CoA hydrolase activity" BROAD
Secondary IDs
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Reactome:R-HSA-193385 "Hydrolysis of choloyl-CoA to cholate and CoASH"
RHEA:19741
RHEA:28542
RHEA:31511
RHEA:38291
RHEA:40219
RHEA:40575
RHEA:40583
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RHEA:40591
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RHEA:45716
RHEA:46224
RHEA:49444
RHEA:59936
RHEA:66704
RHEA:70331
RHEA:70411
RHEA:70415
RHEA:70419
RHEA:70423
RHEA:70427
RHEA:78267