FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term 1-phosphatidylinositol-3-kinase activity ID (Ontology) GO:0016303 (Gene Ontology)
Definition Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + H+.[ EC:2 ]
Also Known As "1-phosphatidylinositol 3-kinase activity" ; "PI3-kinase activity" ; "PI3K" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       3
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
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 Genes
 1-phosphatidylinositol-3-kinase activity (all annotations which use CV term, excluding "NOT" statements)       3
     enables | 1-phosphatidylinositol-3-kinase activity       3
Spanning Tree (Parents/Children)
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lipid kinase activity___________________________________
phosphotransferase activity, alcohol group as acceptor__|
                                                        phosphatidylinositol kinase activity
                                                         |__1-phosphatidylinositol-3-kinase activity  3 rec.
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Is a phosphatidylinositol kinase activity
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Synonyms
  • "1-phosphatidylinositol 3-kinase activity" EXACT
    "phosphatidylinositol 3-kinase activity, class I" NARROW
    "phosphatidylinositol 3-kinase activity, class II" NARROW
    "phosphatidylinositol 3-kinase activity, class III" NARROW
    "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW
    "PI3-kinase activity" EXACT[ EC:2 ]
    "PI3K" EXACT
    "PtdIns-3-kinase activity" EXACT[ EC:2 ]
    "type I phosphatidylinositol kinase activity" NARROW[ EC:2 ]
    "type III phosphoinositide 3-kinase activity" NARROW[ EC:2 ]
Secondary IDs
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EC:2.7.1.137
KEGG_REACTION:R03362
MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN
Reactome:R-HSA-109699 "PI3K-containing complexes phosphorylate PIP2 to PIP3"
Reactome:R-HSA-1433514 "Synthesis of PIP3 from PIP2 by PI3K"
Reactome:R-HSA-1675939 "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane"
Reactome:R-HSA-1675961 "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane"
Reactome:R-HSA-1676024 "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane"
Reactome:R-HSA-2045911 "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3"
Reactome:R-HSA-5672012 "Beclin-1 complex phosphorylates PtdIns"
Reactome:R-HSA-6798174 "PIK3C3:PIK3R4 phosphorylates PI to PI3P"
Reactome:R-HSA-9670433 "KIT mutants:PI3K catalyze synthesis of PIP3"
Reactome:R-HSA-9680389 "CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2"
RHEA:12709