FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term 1-phosphatidylinositol-4-phosphate 5-kinase activity ID (Ontology) GO:0016308 (Gene Ontology)
Definition Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+.[ EC:2 ]
Also Known As"PIP5K"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 1-phosphatidylinositol-4-phosphate 5-kinase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | 1-phosphatidylinositol-4-phosphate 5-kinase activity
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lipid kinase activity___________________________________
phosphotransferase activity, alcohol group as acceptor__|
                                                        phosphatidylinositol kinase activity
                                                         |__1-phosphatidylinositol-4-phosphate 5-kinase activity  2 rec.
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Is a phosphatidylinositol kinase activity
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Synonyms
  • "1-phosphatidylinositol-4-phosphate kinase activity" BROAD
    "1-phosphatidylinositol-4-phosphate kinase, class IA" NARROW
    "1-phosphatidylinositol-4-phosphate kinase, class IB" NARROW
    "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity" RELATED[ EC:2 ]
    "diphosphoinositide kinase activity" BROAD[ EC:2 ]
    "phosphatidylinositol 4-phosphate kinase activity" BROAD[ EC:2 ]
    "phosphatidylinositol-4-phosphate 5-kinase activity" RELATED[ EC:2 ]
    "PI(4)5K" RELATED
    "PIP kinase activity" BROAD[ EC:2 ]
    "PIP5K" EXACT
    "PtdIns(4)P-5-kinase activity" RELATED[ EC:2 ]
    "type I PIP kinase activity" NARROW[ EC:2 ]
Secondary IDs
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EC:2.7.1.68
KEGG_REACTION:R03469
MetaCyc:2.7.1.68-RXN
Reactome:R-HSA-1676082 "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane"
Reactome:R-HSA-3772436 "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2"
Reactome:R-HSA-8868066 "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2"
RHEA:14425
RHEA:40363
RHEA:40367
RHEA:65356