FB2026_03 , released September 17, 2026

CV Term Report

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General Information

Term

1-phosphatidylinositol-5-phosphate 4-kinase activity

ID (Ontology)

GO:0016309 (Gene Ontology)

Definition

Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + H+.[ EC:2 ]

Also Known As

"PIP4K"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
1-phosphatidylinositol-5-phosphate 4-kinase activity (all annotations which use CV term, excluding "NOT" statements)
enables \| 1-phosphatidylinositol-5-phosphate 4-kinase activity

Spanning Tree (Parents/Children)

lipid kinase activity___________________________________
phosphotransferase activity, alcohol group as acceptor__|
                                                        phosphatidylinositol kinase activity
                                                         |__1-phosphatidylinositol-5-phosphate 4-kinase activity  1 rec.

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	phosphatidylinositol kinase activity
Part of
Synonyms & Secondary IDs
Synonyms
	"1-phosphatidylinositol-5-phosphate kinase" BROAD "ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity" RELATED[ EC:2 ] "PIP4K" EXACT "type II PIP kinase activity" NARROW[ EC:2 ]
Secondary IDs

External Crossreferences & Linkouts
	EC:2.7.1.149 MetaCyc:2.7.1.149-RXN Reactome:R-HSA-1675776 "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane" Reactome:R-HSA-6811522 "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus" RHEA:12280 RHEA:55992