FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
Help Close All Open All
General Information
Term phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity ID (Ontology) GO:0016314 (Gene Ontology)
Definition Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate.[ EC:3 ]
Also Known As "PI(3)P 3-phosphatase activity" ; "PI(3,4,5)P3 3-phosphatase activity" ; "PtdIns(3,4,5)P3 3-phosphatase activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       1
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity (all annotations which use CV term, excluding "NOT" statements)       1
     enables | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity       1
Spanning Tree (Parents/Children)
Only view relationship: 
  phosphatidylinositol phosphate phosphatase activity
   |__phosphatidylinositol trisphosphate phosphatase activity
       |__phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  1 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a phosphatidylinositol trisphosphate phosphatase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity" RELATED[ EC:3 ]
    "MMAC1" RELATED[ EC:3 ]
    "phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity" RELATED[ EC:3 ]
    "PI(3)P 3-phosphatase activity" EXACT[ PubMed:15249580 ]
    "PI(3,4,5)P3 3-phosphatase activity" EXACT[ PubMed:15249580 ]
    "PtdIns(3,4,5)P3 3-phosphatase activity" EXACT[ PubMed:15249580 ]
Secondary IDs
hide External Crossreferences & Linkouts
EC:3.1.3.67
MetaCyc:3.1.3.67-RXN
Reactome:R-HSA-199456 "PTEN dephosphorylates PIP3"
Reactome:R-HSA-202237 "Hydrolysis of PIP3 to PI(3,4)P2"
Reactome:R-HSA-2317387 "PTEN cancer mutants do not dephosphorylate PIP3"
RHEA:25017
RHEA:43552
RHEA:43560