FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term CoA-ligase activity ID (Ontology) GO:0016405 (Gene Ontology)
Definition Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA.
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 CoA-ligase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | CoA-ligase activity
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  ligase activity, forming carbon-sulfur bonds
   |__acid-thiol ligase activity
       |__CoA-ligase activity  35 rec.
           |__(E)-caffeate-CoA ligase activity
           |__2-furoate-CoA ligase activity
           |__2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity
           |__3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity
           |__3-hydroxypropionyl-CoA synthetase activity
           |__4-chlorobenzoate-CoA ligase activity
           |__4-coumarate-CoA ligase activity
           |__4-hydroxybenzoate-CoA ligase activity
           |__6-carboxyhexanoate-CoA ligase activity
           |__acetate-CoA ligase (ADP-forming) activity
           |__acetoacetate-CoA ligase activity
           |__acetyl-CoA synthetase activity 3 rec.
           |__acid-CoA ligase (GDP-forming) activity
           |__anthranilate-CoA ligase activity
           |__benzoate-CoA ligase activity
           |__biotin-CoA ligase activity
           |__carnitine-CoA ligase activity
           |__cholate-CoA ligase activity
           |__citrate-CoA ligase activity
           |__crotonobetaine-CoA ligase activity
           |__dicarboxylate-CoA ligase activity
           |__fatty acid-CoA ligase activity 25 rec.
           |   |__long-chain fatty acid-CoA ligase activity(+) 21 rec.
           |   |__medium-chain fatty acid-CoA ligase activity(+) 1 rec.
           |   |__short-chain fatty acid-CoA ligase activity(+) 1 rec.
           |   |__very long-chain fatty acid-CoA ligase activity 2 rec.
           |__glutarate-CoA ligase activity
           |__malate-CoA ligase activity
           |__malonyl-CoA synthetase activity 1 rec.
           |__o-succinylbenzoate-CoA ligase activity
           |__oxalate-CoA ligase activity
           |__perillic acid-CoA ligase (AMP-forming) activity
           |__phenylacetate-CoA ligase activity
           |__phytanate-CoA ligase activity
           |__pristanate-CoA ligase activity
           |__succinate-CoA ligase activity 7 rec.
           |   |__succinate-CoA ligase (ADP-forming) activity 4 rec.
           |   |__succinate-CoA ligase (GDP-forming) activity 4 rec.
           |__trans-cinnamate-CoA ligase activity
           |__trans-feruloyl-CoA synthase activity
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Is a acid-thiol ligase activity
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Reactome:R-HSA-159443 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate"
Reactome:R-HSA-159567 "ACSM2B-like proteins transform ST to ST-CoA"
Reactome:R-HSA-177157 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate"
Reactome:R-HSA-9749971 "ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA"