FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
Help Close All Open All
General Information
Term tRNA (cytidine-N5)-methyltransferase activity ID (Ontology) GO:0016428 (Gene Ontology)
Definition Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on several residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49).
Also Known As "tRNA (cytidine-5-)-methyltransferase activity" ; "tRNA (cytosine-5-)-methyltransferase activity"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       3
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 tRNA (cytidine-N5)-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)       3
     enables | tRNA (cytidine-N5)-methyltransferase activity       3
Spanning Tree (Parents/Children)
Only view relationship: 
tRNA methyltransferase activity____________________________
S-adenosylmethionine-dependent methyltransferase activity__|
                                                           tRNA (cytidine) methyltransferase activity
                                                            |__tRNA (cytidine-N5)-methyltransferase activity  3 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a tRNA (cytidine) methyltransferase activity
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity" RELATED
    "transfer ribonucleate cytosine 5-methyltransferase activity" RELATED
    "transfer RNA cytosine 5-methyltransferase activity" RELATED
    "tRNA (cytidine-5-)-methyltransferase activity" EXACT
    "tRNA (cytosine-5-)-methyltransferase activity" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
EC:2.1.1.202
Reactome:R-HSA-6782388 "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)"
Reactome:R-HSA-6782419 "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)"
Reactome:R-HSA-6785409 "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)"
Reactome:R-HSA-6785438 "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)"
Reactome:R-HSA-8932765 "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)"
RHEA:21124
RHEA:42940
RHEA:42944
RHEA:42948
RHEA:42952
RHEA:42956
RHEA:51160
RHEA:51164
RHEA:51172
RHEA:51176
RHEA:51180
RHEA:53076
RHEA:54136
RHEA:54140
RHEA:61468
RHEA:61488
RHEA:61584
RHEA:61988