FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term tRNA (cytidine-N5)-methyltransferase activity ID (Ontology) GO:0016428 (Gene Ontology)
Definition Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on several residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49).
Also Known As"tRNA (cytidine-5-)-methyltransferase activity" ; "tRNA (cytosine-5-)-methyltransferase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 tRNA (cytidine-N5)-methyltransferase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | tRNA (cytidine-N5)-methyltransferase activity
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tRNA methyltransferase activity____________________________
S-adenosylmethionine-dependent methyltransferase activity__|
                                                           tRNA (cytidine) methyltransferase activity
                                                            |__tRNA (cytidine-N5)-methyltransferase activity  3 rec.
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Is a tRNA (cytidine) methyltransferase activity
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Synonyms
  • "S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity" RELATED
    "transfer ribonucleate cytosine 5-methyltransferase activity" RELATED
    "transfer RNA cytosine 5-methyltransferase activity" RELATED
    "tRNA (cytidine-5-)-methyltransferase activity" EXACT
    "tRNA (cytosine-5-)-methyltransferase activity" EXACT
Secondary IDs
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EC:2.1.1.202
Reactome:R-HSA-6782388 "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)"
Reactome:R-HSA-6782419 "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)"
Reactome:R-HSA-6785409 "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)"
Reactome:R-HSA-6785438 "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)"
Reactome:R-HSA-8932765 "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)"
RHEA:21124
RHEA:42940
RHEA:42944
RHEA:42948
RHEA:42952
RHEA:42956
RHEA:51160
RHEA:51164
RHEA:51172
RHEA:51176
RHEA:51180
RHEA:53076
RHEA:54136
RHEA:54140
RHEA:61468
RHEA:61488
RHEA:61584
RHEA:61988