FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term core-binding factor complex ID (Ontology) GO:0016513 (Gene Ontology)
Definition A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit.[ PubMed:15156179 PubMed:8497254 ]
Also Known As"CBF complex"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
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 core-binding factor complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | core-binding factor complex
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transcription regulator complex_____
nuclear protein-containing complex__|
                                    RNA polymerase II transcription regulator complex
                                     |__core-binding factor complex  2 rec.
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Is a RNA polymerase II transcription regulator complex
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Synonyms
  • "AML1 complex" NARROW
    "CBF complex" EXACT
    "PEPB2 complex" NARROW
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