FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term mediator complex ID (Ontology) GO:0016592 (Gene Ontology)
Definition A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.[ PubMed:11454195 PubMed:16168358 PubMed:17870225 ]
Also Known As"L mediator complex" ; "Srb-mediator complex"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_BIOLOGICAL_PROCESS
Genes (FBgn)GO_CELLULAR_COMPONENT
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 mediator complex (all annotations which use CV term, excluding "NOT" statements)
     part_of | mediator complex       --
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nucleus_____________________
protein-containing complex__|
                            nuclear protein-containing complex
                             |__mediator complex  35 rec.
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Is a nuclear protein-containing complex
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Synonyms
  • "CDK8-containing TRAP/mediator complex" RELATED
    "L mediator complex" EXACT
    "Srb-mediator complex" EXACT
    "TRAP complex" NARROW
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Wikipedia:Mediator_(coactivator)