FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ID (Ontology) GO:0016616 (Gene Ontology)
Definition Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.[ EC:1 ]
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Genes (FBgn)  GO_MOLECULAR_FUNCTION      44
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 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (all annotations which use CV term, excluding "NOT" statements)       2     44
     enables | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor       --      44
Spanning Tree (Parents/Children)
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  oxidoreductase activity
   |__oxidoreductase activity, acting on CH-OH group of donors
       |__oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  127 rec.
           |__(+)-borneol dehydrogenase activity
           |__(+)-neomenthol dehydrogenase activity
           |__(+)-sabinol dehydrogenase activity
           |__(+)-trans-carveol dehydrogenase activity
           |__(-)-borneol dehydrogenase activity
           |__(-)-menthol dehydrogenase activity
           |__(2R)-2-hydroxyacid dehydrogenase (NAD+) activity
           |   |__(2R)-hydroxyphenylpyruvate reductase [NAD(P)H] activity
           |   |__D-lactate dehydrogenase (NAD+) activity
           |   |__phenyllactate dehydrogenase (NAD+) activity
           |__(2R)-2-hydroxyacid dehydrogenase (NADP+) activity
           |__(3R)-2'-hydroxyisoflavanone reductase (NADP+) activity
           |__(3R)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity 1 rec.
           |__(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity 2 rec.
           |   |__long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity 1 rec.
           |__(R)-2-hydroxy-fatty acid dehydrogenase (NAD+) activity
           |__(R)-2-hydroxyglutarate (NAD+) dehydrogenase activity
           |__(R)-2-hydroxyisocaproate dehydrogenase activity
           |__(R)-3-hydroxyacid-ester dehydrogenase activity
           |__(R)-4-hydroxyphenyllactate dehydrogenase (NADP+) activity
           |__(R)-aminopropanol dehydrogenase activity
           |__(R)-lactaldehyde dehydrogenase activity
           |__(R)-mandelate dehydrogenase activity
           |__(R)-sulfopropanediol 2-dehydrogenase activity
           |__(R,R)-butanediol dehydrogenase activity
           |__(S)-2-hydroxy-fatty acid dehydrogenase activity
           |__(S)-3-hydroxyacid-ester dehydrogenase activity
           |__(S)-carnitine 3-dehydrogenase activity
           |__(S)-usnate reductase activity
           |__(S,S)-butanediol dehydrogenase activity
           |__1,3-propanediol dehydrogenase activity
           |__1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity
           |__1,5-anhydro-D-fructose reductase activity
           |__1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
           |__2,5-didehydrogluconate reductase activity
           |__2-(R)-hydroxypropyl-CoM dehydrogenase activity
           |__2-(S)-hydroxypropyl-CoM dehydrogenase activity
           |__2-alkyn-1-ol dehydrogenase activity
           |__2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity
           |__2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity
           |__2-dehydropantoate 2-reductase activity
           |__2-dehydropantolactone reductase activity
           |   |__2-dehydropantolactone reductase (A-specific) activity
           |   |__2-dehydropantolactone reductase (B-specific) activity
           |__2-deoxy-D-gluconate 3-dehydrogenase activity
           |__2-hydroxy-3-oxopropionate reductase activity
           |__2-hydroxymethylglutarate dehydrogenase activity
           |__2-oxoadipate reductase activity
           |__3''-deamino-3''-oxonicotianamine reductase activity
           |__3-(imidazol-5-yl)lactate dehydrogenase activity
           |__3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity
           |__3-alpha-hydroxycholanate dehydrogenase activity
           |__3-alpha-hydroxyglycyrrhetinate dehydrogenase activity
           |__3-dehydro-L-gulonate 2-dehydrogenase activity
           |__3-dehydrosphinganine reductase activity 1 rec.
           |__3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity 1 rec.
           |__3-hydroxybenzyl-alcohol dehydrogenase activity
           |__3-hydroxybutyrate dehydrogenase activity 1 rec.
           |__3-hydroxybutyryl-CoA dehydrogenase activity
           |__3-hydroxyisobutyrate dehydrogenase activity 1 rec.
           |__3-hydroxypimeloyl-CoA dehydrogenase activity
           |__3-hydroxypropionate dehydrogenase (NAD+) activity
           |__3-hydroxypropionate dehydrogenase (NADP+) activity
           |__3-isopropylmalate dehydrogenase activity
           |__3-ketoglucose-reductase activity
           |__3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity
           |__3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity 1 rec.
           |__3-sulfolactaldehyde reductase activity
           |__3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase activity
           |__4-(hydroxymethyl)benzenesulfonate dehydrogenase activity
           |__4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity
           |__4-hydroxy-L-isoleucine dehydrogenase activity
           |__4-hydroxybutyrate dehydrogenase activity
           |__4-hydroxycyclohexanecarboxylate dehydrogenase activity
           |__4-hydroxythreonine-4-phosphate dehydrogenase activity
           |__4-oxoproline reductase activity
           |__4-phosphoerythronate dehydrogenase activity
           |__5'-hydroxyaverantin dehydrogenase activity
           |__5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity
           |__5-amino-6-(5-phosphoribosylamino)uracil reductase activity
           |__5-exo-hydroxycamphor dehydrogenase activity
           |__6-endo-hydroxycineole dehydrogenase activity
           |__6-hydroxyhexanoate dehydrogenase activity
           |__6-pyruvoyltetrahydropterin 2'-reductase activity
           |__8-hydroxygeraniol dehydrogenase activity
           |__8-oxocoformycin reductase activity
           |__10-hydroxygeranial oxidoreductase activity
           |__10-hydroxygeraniol oxidoreductase activity
           |__10-oxogeraniol oxidoreductase activity
           |__11-deoxycorticosterone reductase activity
           |__13-lipoxin reductase activity
           |__15-hydroxyicosatetraenoate dehydrogenase activity
           |__15-hydroxyprostaglandin dehydrogenase (NAD+) activity
           |__15-hydroxyprostaglandin dehydrogenase (NADP+) activity
           |__15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
           |__15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity
           |__16-hydroxypalmitate dehydrogenase activity
           |__acetoacetyl-CoA reductase activity
           |__acetoin dehydrogenase (NAD+) activity
           |   |__diacetyl reductase ((R)-acetoin forming) (NAD+) activity
           |   |__diacetyl reductase ((S)-acetoin forming) (NAD+) activity
           |__acylglycerone-phosphate reductase (NADP+) activity 1 rec.
           |__alcohol dehydrogenase [NAD(P)+] activity 43 rec.
           |   |__3-methylbutanal reductase [NAD(P)H] activity(+)
           |   |__alcohol dehydrogenase (NAD+) activity(+) 15 rec.
           |   |__alcohol dehydrogenase (NADP+) activity(+) 28 rec.
           |__aldose 1-dehydrogenase activity
           |__aldose-6-phosphate reductase (NADPH) activity
           |__allyl-alcohol dehydrogenase activity
           |__apiose 1-reductase activity
           |__aryl-alcohol dehydrogenase (NADP+) activity
           |__bacteriochlorophyllide-a dehydrogenase activity
           |__benzyl-2-methyl-hydroxybutyrate dehydrogenase activity
           |__cardiolipin dehydrogenase (NAD+) activity 1 rec.
           |__carnitine 3-dehydrogenase activity
           |__carveol dehydrogenase activity
           |__chlordecone reductase activity
           |__chlorophyll(ide) b reductase activity
           |__cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
           |__cinnamyl-alcohol dehydrogenase activity
           |__codeinone reductase (NADPH) activity
           |__coniferyl-alcohol dehydrogenase activity
           |__cyclohexane-1,2-diol dehydrogenase activity
           |__cyclohexanol dehydrogenase activity
           |__cyclopentanol dehydrogenase activity
           |__D-arabinitol 2-dehydrogenase activity
           |__D-arabinitol 4-dehydrogenase activity
           |__D-arabinitol dehydrogenase (NADP+) activity
           |__D-arabinose 1-dehydrogenase [NAD(P)+] activity
           |   |__D-arabinose 1-dehydrogenase (NAD+) activity
           |   |__D-arabinose 1-dehydrogenase (NADP+) activity
           |__D-fructuronate reductase activity
           |__D-galacturonate reductase activity
           |__D-iditol 2-dehydrogenase activity
           |__D-malate dehydrogenase (decarboxylating) (NAD+) activity
           |__D-pinitol dehydrogenase activity
           |__D-threo-aldose 1-dehydrogenase activity 6 rec.
           |__D-xylose 1-dehydrogenase (NAD+) activity
           |__D-xylose 1-dehydrogenase (NADP+) activity 3 rec.
           |__D-xylulose reductase activity 1 rec.
           |__diethyl 2-methyl-3-oxosuccinate reductase activity
           |__dihydrobunolol dehydrogenase activity
           |__dihydroflavanol 4-reductase activity
           |__diiodophenylpyruvate reductase (NAD+) activity
           |__dimethylmalate dehydrogenase activity
           |__dTDP-4-dehydro-6-deoxyglucose reductase activity
           |__dTDP-4-dehydrorhamnose reductase activity
           |__dTDP-6-deoxy-L-talose 4-dehydrogenase activity
           |__dTDP-galactose 6-dehydrogenase activity
           |__erythrulose reductase activity
           |__farnesol dehydrogenase activity
           |__flavanone 4-reductase activity
           |__fluoren-9-ol dehydrogenase activity
           |__fructose 5-dehydrogenase (NADP+) activity
           |__fructuronate reductase activity
           |__galactitol 2-dehydrogenase activity
           |__galactitol-1-phosphate 5-dehydrogenase activity
           |__galactose 1-dehydrogenase (NADP+) activity
           |__galactose 1-dehydrogenase activity
           |__GDP-4-dehydro-6-deoxy-D-mannose reductase activity
           |__GDP-4-dehydro-D-rhamnose reductase activity
           |__GDP-6-deoxy-D-talose 4-dehydrogenase activity
           |__GDP-L-fucose synthase activity 1 rec.
           |__GDP-mannose 6-dehydrogenase activity
           |__geraniol dehydrogenase activity
           |__gluconate dehydrogenase activity
           |   |__gluconate 2-dehydrogenase (acceptor) activity
           |   |__gluconate 2-dehydrogenase activity
           |   |__gluconate 5-dehydrogenase activity
           |__glucose 1-dehydrogenase [NAD(P)+] activity
           |   |__glucose 1-dehydrogenase (NAD+) activity
           |   |__glucose 1-dehydrogenase (NADP+) activity
           |__glucose-6-phosphate 3-dehydrogenase activity
           |__glucose-6-phosphate dehydrogenase activity 1 rec.
           |__glucuronolactone reductase activity
           |__glycerol 2-dehydrogenase (NADP+) activity
           |__glycerol dehydrogenase (NAD+) activity
           |__glycerol dehydrogenase (NADP+) activity
           |__glycerol-1-phosphate dehydrogenase [NAD(P)+] activity
           |   |__glycerol-1-phosphate dehydrogenase (NAD+) activity
           |   |__glycerol-1-phosphate dehydrogenase (NADP+) activity
           |__glycerol-3-phosphate 1-dehydrogenase (NADP+) activity
           |__glycerol-3-phosphate dehydrogenase [NAD(P)+] activity 4 rec.
           |   |__glycerol-3-phosphate dehydrogenase (NAD+) activity 4 rec.
           |   |__glycerol-3-phosphate dehydrogenase (NADP+) activity
           |__glyoxylate reductase activity 5 rec.
           |   |__glyoxylate reductase (NADH) activity
           |   |__glyoxylate reductase (NADPH) activity 5 rec.
           |__histidinol dehydrogenase activity
           |__homoisocitrate dehydrogenase activity
           |__homoserine dehydrogenase activity
           |__hydroxycyclohexanecarboxylate dehydrogenase activity
           |__hydroxymalonate dehydrogenase activity
           |__hydroxymethylfurfural reductase (NADH) activity
           |__hydroxymethylfurfural reductase (NADPH) activity
           |__hydroxymethylglutaryl-CoA reductase (NADH) activity
           |__hydroxymethylglutaryl-CoA reductase (NADPH) activity 1 rec.
           |__hydroxypyruvate reductase [NAD(P)H] activity 5 rec.
           |   |__hydroxypyruvate reductase (NADH) activity 5 rec.
           |   |__hydroxypyruvate reductase (NADPH) activity
           |__hydroxyversicolorone reductase activity
           |__IMP dehydrogenase activity 1 rec.
           |__indanol dehydrogenase activity
           |__indole-3-acetaldehyde reductase (NADPH) activity
           |__indolelactate dehydrogenase (NAD+) activity
           |__isocitrate dehydrogenase [NAD(P)+] activity 6 rec.
           |   |__isocitrate dehydrogenase (NAD+) activity 4 rec.
           |   |__isocitrate dehydrogenase (NADP+) activity 1 rec.
           |__isocitrate-homoisocitrate dehydrogenase activity
           |__isopiperitenol dehydrogenase activity
           |__isopropanol dehydrogenase (NADP+) activity
           |__ketol-acid reductoisomerase activity
           |__L-2-hydroxycarboxylate dehydrogenase (NAD+) activity 2 rec.
           |   |__L-lactate dehydrogenase (NAD+) activity 2 rec.
           |__L-arabinitol 2-dehydrogenase activity
           |__L-arabinitol 4-dehydrogenase activity
           |__L-arabinose 1-dehydrogenase (NAD+) activity
           |__L-arabinose 1-dehydrogenase (NADP+) activity
           |__L-galactose dehydrogenase activity 3 rec.
           |__L-glucuronate reductase activity 1 rec.
           |__L-glyceraldehyde 3-phosphate reductase activity
           |__L-glycol dehydrogenase activity
           |__L-gulonate 3-dehydrogenase activity 3 rec.
           |__L-idonate 5-dehydrogenase [NAD(P)+] activity
           |   |__L-idonate 5-dehydrogenase (NAD+) activity
           |__L-malate dehydrogenase (NAD+) activity 5 rec.
           |__L-malate dehydrogenase (NADP+) activity
           |__L-rhamnose 1-dehydrogenase activity
           |__L-threonate 3-dehydrogenase activity
           |__L-threonine 3-dehydrogenase activity 1 rec.
           |__L-xylose 1-dehydrogenase activity
           |__L-xylulose reductase (NADH) activity
           |__L-xylulose reductase (NADPH) activity 1 rec.
           |__lactaldehyde reductase (NADPH) activity
           |__lactaldehyde reductase activity
           |   |__R-lactaldehyde reductase activity
           |   |__S-lactaldehyde reductase activity
           |__long-chain-alcohol dehydrogenase activity
           |__malate dehydrogenase (decarboxylating) (NAD+) activity
           |__malate dehydrogenase (decarboxylating) (NADP+) activity 5 rec.
           |__mannitol 2-dehydrogenase (NADP+) activity
           |__mannitol 2-dehydrogenase activity
           |__mannitol dehydrogenase activity
           |__mannitol-1-phosphate 5-dehydrogenase activity
           |__mannose-6-phosphate 6-reductase activity
           |__mannuronate reductase activity
           |__methylglyoxal reductase (NADH) activity
           |__methylglyoxal reductase (NADPH) (acetol producing) activity
           |__methylglyoxal reductase (NADPH) activity
           |__mithramycin dehydrogenase (NADPH) activity
           |__momilactone-A synthase [NAD(P)H] activity
           |__morphine 6-dehydrogenase activity
           |__N-acetylhexosamine 1-dehydrogenase activity
           |__N-acylmannosamine 1-dehydrogenase activity
           |__omega-hydroxydecanoate dehydrogenase activity
           |__oxaloglycolate reductase (decarboxylating) activity
           |__pantoate 4-dehydrogenase activity
           |__phenylacetaldehyde reductase activity
           |__phenylcoumaran benzylic ether reductase activity
           |__phosphatidylglycerol dehydrogenase (NAD+) activity
           |__phosphogluconate 2-dehydrogenase activity
           |__phosphogluconate dehydrogenase (decarboxylating) activity 1 rec.
           |__phosphoglycerate dehydrogenase activity 1 rec.
           |__propanediol-phosphate dehydrogenase activity
           |__prostaglandin D2 11-ketoreductase activity
           |__prostaglandin E2 9-reductase activity
           |__prostaglandin F synthase activity
           |__prostaglandin H2 endoperoxidase reductase activity 1 rec.
           |__pyridoxal 4-dehydrogenase activity
           |__quinate 3-dehydrogenase (NAD+) activity
           |__quinate 3-dehydrogenase (NADP+) activity
           |__ribitol 2-dehydrogenase (NAD+) activity
           |__ribitol-5-phosphate 2-dehydrogenase [NAD(P)+] activity
           |__ribose 1-dehydrogenase (NADP+) activity
           |__S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity 1 rec.
           |   |__S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity
           |   |__S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity
           |__S-nitrosoglutathione reductase (NADH) activity 1 rec.
           |__S-nitrosoglutathione reductase (NADPH) activity
           |__S-sulfolactate dehydrogenase activity
           |__salutaridine reductase (NADPH) activity
           |__scyllo-inositol dehydrogenase (NADP+) activity
           |__secoisolariciresinol dehydrogenase activity
           |__sepiapterin reductase (NADP+) activity 2 rec.
           |__sequoyitol dehydrogenase activity
           |__serine 3-dehydrogenase activity
           |__shikimate 3-dehydrogenase (NAD+) activity
           |__shikimate 3-dehydrogenase (NADP+) activity
           |__sorbitol-6-phosphate 2-dehydrogenase activity
           |__sorbose 5-dehydrogenase (NADP+) activity
           |__sorbose reductase activity
           |__steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 12 rec.
           |   |__3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity
           |   |__3-beta-hydroxy-5-alpha-steroid dehydrogenase (NADP+) activity
           |   |__3-beta-hydroxy-5-beta-steroid dehydrogenase (NADP+) activity
           |   |__3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity(+) 1 rec.
           |   |__3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity 8 rec.
           |   |__3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity(+)
           |   |__5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity
           |   |__7-beta-hydroxysteroid dehydrogenase (NADP+) activity
           |   |__11-beta-hydroxysteroid dehydrogenase (NAD+) activity
           |   |__11-beta-hydroxysteroid dehydrogenase (NADP+) activity(+)
           |   |__12-beta-hydroxysteroid dehydrogenase (NADP+) activity
           |   |__17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity
           |   |__17-beta-hydroxysteroid dehydrogenase (NAD+) activity(+) 1 rec.
           |   |__17-beta-hydroxysteroid dehydrogenase (NADP+) activity(+) 8 rec.
           |   |__androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
           |   |__androsterone dehydrogenase [NAD(P)+] activity
           |   |__chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
           |   |__cholate 7-alpha-dehydrogenase (NAD+) activity
           |   |__cholate 12-alpha dehydrogenase (NADP+) activity
           |   |__estradiol 17-alpha-dehydrogenase [NAD(P)+] activity
           |   |__estradiol 17-beta-dehydrogenase [NAD(P)+] activity 10 rec.
           |   |__isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
           |   |__pregnan-21-ol dehydrogenase (NAD+) activity
           |   |__pregnan-21-ol dehydrogenase (NADP+) activity
           |   |__ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
           |__sulcatone reductase activity
           |__tagaturonate reductase activity
           |__tartrate dehydrogenase activity
           |__tetrahydroxynaphthalene reductase activity
           |__tropine dehydrogenase activity
           |__tropinone reductase activity
           |__UDP-3-dehydro-alpha-D-glucose dehydrogenase activity
           |__UDP-4-keto-rhamnose-4-keto-reductase activity
           |__UDP-glucose 6-dehydrogenase activity 1 rec.
           |__UDP-glucuronate dehydrogenase activity
           |__UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity
           |__UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity
           |__UDP-N-acetyl-D-mannosamine dehydrogenase activity
           |__UDP-N-acetylglucosamine 6-dehydrogenase activity
           |__UDP-N-acetylmuramate dehydrogenase activity
           |__ureidoglycolate dehydrogenase activity
           |__uronate dehydrogenase activity
           |__vellosimine dehydrogenase activity
           |__versiconal hemiacetal acetate reductase activity
           |__versiconal reductase activity
           |__very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
           |__very-long-chain 3-oxoacyl-CoA reductase activity 6 rec.
           |__vomifoliol 4'-dehydrogenase activity
           |__zerumbone synthase activity
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Is a oxidoreductase activity, acting on CH-OH group of donors
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EC:1.1.1.-
MetaCyc:RXN-12898
Reactome:R-HSA-9027625 "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3"
Reactome:R-HSA-9027631 "5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA"
Reactome:R-HSA-9027632 "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA"
Reactome:R-HSA-975629 "RDH11 reduces RBP2:atRAL to RBP2:atROL"
RHEA:25968