FB2026_03 , released September 17, 2026
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Term oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ID (Ontology) GO:0016628 (Gene Ontology)
Definition Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.[ EC:1 ]
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 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor (all annotations which use CV term, excluding "NOT" statements)
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  oxidoreductase activity
   |__oxidoreductase activity, acting on the CH-CH group of donors
       |__oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor  13 rec.
           |__(+)-pulegone reductase (NADP+) activity
           |__(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity
           |__1,2-dihydrovomilenine reductase activity
           |__1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity
           |__1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity
           |__2'-hydroxydaidzein reductase activity
           |__2'-hydroxyisoflavone reductase activity
           |__2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
           |__2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity
           |__2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity
           |__2,4-dienoyl-CoA reductase (NADPH) activity
           |__2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity
           |__2-alkenal reductase [NAD(P)H] activity
           |   |__2-alkenal reductase (NADPH) activity
           |__2-chloroacrylate reductase activity
           |__2-coumarate reductase activity
           |__2-enoate reductase activity
           |__2-hexadecenal reductase activity
           |__2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity
           |__3,8-divinyl protochlorophyllide a 8-vinyl-reductase (NADPH) activity
           |__3-methyleneoxindole reductase activity
           |__5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity
           |__7-dehydrocholesterol reductase activity
           |__11-hydroxythromboxane B2 dehydrogenase activity
           |__12-hydroxyheptadecatrienoic acid synthase activity
           |__12-oxophytodienoate reductase activity
           |__15-oxoprostaglandin 13-reductase [NAD(P)+] activity
           |__acrolein reductase activity
           |__acryloyl-CoA reductase (NADH) activity
           |__acryloyl-CoA reductase (NADPH) activity
           |__acyl-CoA dehydrogenase (NADP+) activity
           |__alpha-santonin 1,2-reductase activity
           |__anthocyanidin reductase activity
           |__arogenate dehydrogenase [NAD(P)+] activity
           |   |__arogenate dehydrogenase (NADP+) activity
           |__beta-nitroacrylate reductase activity
           |__biliverdin reductase [NAD(P)H] activity 1 rec.
           |   |__biliberdin reductase (NADH) activity
           |   |__biliverdin reductase (NADPH) activity
           |__biochanin-A reductase activity
           |__cinnamate reductase activity
           |__cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity
           |__cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
           |__cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
           |__cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity
           |__cis-2-enoyl-CoA reductase (NADPH) activity
           |__cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity
           |__cis-dihydroethylcatechol dehydrogenase activity
           |__citronellyl-CoA dehydrogenase activity
           |__crotonyl-CoA reductase activity
           |__curcumin reductase (NADP+) activity
           |__cyclohexadienyl dehydrogenase activity
           |__Delta14-sterol reductase activity
           |__Delta24(24-1) sterol reductase activity
           |__Delta24-sterol reductase activity
           |__dibenzothiophene dihydrodiol dehydrogenase activity
           |__dihydroorotate dehydrogenase (NAD+) activity
           |__dihydroorotate dehydrogenase (NADP+) activity
           |__dihydropyrimidine dehydrogenase (NAD+) activity
           |__dihydropyrimidine dehydrogenase (NADP+) activity 1 rec.
           |__dolichal reductase (NADPH) activity 1 rec.
           |__enone reductase activity 1 rec.
           |   |__(-)-isopiperitenone reductase activity
           |   |__3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity 1 rec.
           |   |__Delta4-3-oxosteroid 5beta-reductase activity
           |__enoyl-[acyl-carrier-protein] reductase [NAD(P)H] activity 1 rec.
           |   |__enoyl-[acyl-carrier-protein] reductase (NADH) activity
           |   |__enoyl-[acyl-carrier-protein] reductase (NADPH) activity 1 rec.
           |__fumarate reductase (NADH) activity
           |__furaneol oxidoreductase activity
           |__geissoschizine dehydrogenase activity
           |__geranylgeranyl diphosphate reductase activity
           |__kynurenate-7,8-dihydrodiol dehydrogenase activity
           |__maleylacetate reductase activity
           |__meso-tartrate dehydrogenase activity
           |__N-ethylmaleimide reductase activity
           |__phloroglucinol reductase activity
           |__phthalate 4,5-cis-dihydrodiol dehydrogenase activity
           |__pimeloyl-CoA dehydrogenase activity
           |__polyprenal reductase activity 1 rec.
           |__polyprenol dehydrogenase (NAD+) activity 1 rec.
           |__polyprenol reductase activity
           |__precorrin-2 dehydrogenase activity
           |__precorrin-6A reductase activity
           |__prephenate dehydrogenase (NAD+) activity
           |__prephenate dehydrogenase (NADP+) activity
           |__protochlorophyllide reductase activity
           |__RNA dihydrouridine synthase activity 5 rec.
           |   |__mRNA dihydrouridine synthase activity
           |   |__tRNA dihydrouridine synthase activity(+) 5 rec.
           |__trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
           |__trans-2-enoyl-CoA reductase (NADH) activity
           |__trans-2-enoyl-CoA reductase (NADPH) activity
           |__trans-4-hexen-3-one reductase activity
           |__UDP-N-acetylmuramate dehydrogenase activity
           |__very-long-chain enoyl-CoA reductase activity 1 rec.
           |__xanthommatin reductase activity
           |__zeatin reductase activity
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Is a oxidoreductase activity, acting on the CH-CH group of donors
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EC:1.3.1.-
Reactome:R-HSA-4755572 "Defective SRD5A3 does not reduce pPNOL to DCHOL"
Reactome:R-HSA-9661726 "An unknown reductase reduces D-UBGN to STBN"
Reactome:R-HSA-9661745 "An unknown BILR reduces BIL to D-UBGN"