FB2026_03 , released September 17, 2026
CV Term Report
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Term oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ID (Ontology) GO:0016702 (Gene Ontology)
Definition Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor.
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 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (all annotations which use CV term, excluding "NOT" statements)
     enables | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
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oxidoreductase activity
 |__oxidoreductase activity, acting on single donors with incorporation of molecular oxygen__
 |__dioxygenase activity_____________________________________________________________________|
                                                                                         oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen  8 rec.
                                                                                          |__1,2-dihydroxynaphthalene dioxygenase activity
                                                                                          |__1-hydroxy-2-naphthoate 1,2-dioxygenase activity
                                                                                          |__2,3-dihydroxy-p-cumate dioxygenase activity
                                                                                          |__2,3-dihydroxybenzoate 2,3-dioxygenase activity
                                                                                          |__2,3-dihydroxybenzoate 3,4-dioxygenase activity
                                                                                          |__2,3-dihydroxybiphenyl 1,2-dioxygenase activity
                                                                                          |__2,3-dihydroxyindole 2,3-dioxygenase activity
                                                                                          |__2,4'-dihydroxyacetophenone dioxygenase activity
                                                                                          |__2,5-dihydroxypyridine 5,6-dioxygenase activity
                                                                                          |__3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity
                                                                                          |__3,4-dihydroxyphenylacetate 2,3-dioxygenase activity
                                                                                          |__3-carboxyethylcatechol 2,3-dioxygenase activity
                                                                                          |__3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity
                                                                                          |__3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity
                                                                                          |__3-hydroxyanthranilate 3,4-dioxygenase activity
                                                                                          |__4-hydroxymandelate synthase activity
                                                                                          |__4-hydroxyphenylpyruvate dioxygenase activity 1 rec.
                                                                                          |__5,6-dimethylbenzimidazole synthase activity
                                                                                          |__7,8-dihydroxykynurenate 8,8a-dioxygenase activity
                                                                                          |__9-cis-10'-apo-beta-carotenal cleavage oxygenase activity
                                                                                          |__9-cis-beta-carotene 9',10'-cleavage oxygenase activity
                                                                                          |__acetylacetone-cleaving enzyme activity
                                                                                          |__acireductone dioxygenase (Ni2+-requiring) activity 1 rec.
                                                                                          |__acireductone dioxygenase [iron(II)-requiring] activity 1 rec.
                                                                                          |__all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity
                                                                                          |__all-trans-beta-apo-10'-carotenal cleavage oxygenase activity
                                                                                          |__apo-beta-carotenoid-14',13'-dioxygenase activity
                                                                                          |__arachidonate 5-lipoxygenase activity
                                                                                          |__arachidonate 8(R)-lipoxygenase activity
                                                                                          |__arachidonate 8(S)-lipoxygenase activity
                                                                                          |__arachidonate 12(R)-lipoxygenase activity
                                                                                          |__arachidonate 12(S)-lipoxygenase activity
                                                                                          |__arachidonate 15-lipoxygenase activity
                                                                                          |__beta,beta-carotene-9',10'-cleaving oxygenase activity
                                                                                          |__beta-carotene 15,15'-dioxygenase activity 1 rec.
                                                                                          |__biphenyl-2,3-diol 1,2-dioxygenase activity
                                                                                          |__caffeate 3,4-dioxygenase activity
                                                                                          |__carotenoid dioxygenase activity 1 rec.
                                                                                          |   |__9,10 (9', 10')-carotenoid-cleaving dioxygenase activity
                                                                                          |   |__9-cis-epoxycarotenoid dioxygenase activity
                                                                                          |   |__carotenoid isomerooxygenase activity 1 rec.
                                                                                          |__catechol 1,2-dioxygenase activity
                                                                                          |__catechol 2,3-dioxygenase activity
                                                                                          |__chloridazon-catechol dioxygenase activity
                                                                                          |__chlorite O2-lyase activity
                                                                                          |__cysteamine dioxygenase activity 1 rec.
                                                                                          |__cysteine dioxygenase activity 1 rec.
                                                                                          |__fatty acid alpha-dioxygenase activity
                                                                                          |__gallate dioxygenase activity
                                                                                          |__gentisate 1,2-dioxygenase activity
                                                                                          |__homogentisate 1,2-dioxygenase activity 1 rec.
                                                                                          |__hydroxyquinol 1,2-dioxygenase activity
                                                                                          |__indole 2,3-dioxygenase activity
                                                                                          |__indoleamine 2,3-dioxygenase activity
                                                                                          |__L-tryptophan 2,3-dioxygenase activity 1 rec.
                                                                                          |__lignostilbene alpha beta-dioxygenase activity
                                                                                          |__linoleate 8R-lipoxygenase activity
                                                                                          |__linoleate 9S-lipoxygenase activity
                                                                                          |__linoleate 11-lipoxygenase activity
                                                                                          |__linoleate 13S-lipoxygenase activity
                                                                                          |__linolenate 9R-lipoxygenase activity
                                                                                          |__protocatechuate 3,4-dioxygenase activity
                                                                                          |__protocatechuate 4,5-dioxygenase activity
                                                                                          |__pyrogallol 1,2-oxygenase activity
                                                                                          |__quercetin 2,3-dioxygenase activity
                                                                                          |__questin hydroquinone dioxygenase activity
                                                                                          |__resveratrol dioxygenase activity
                                                                                          |__stizolobate synthase activity
                                                                                          |__stizolobinate synthase activity
                                                                                          |__sulfur dioxygenase activity 1 rec.
                                                                                          |__sulfur oxygenase/reductase activity
                                                                                          |__violaxanthin oxygenase activity
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Is a oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
dioxygenase activity
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EC:1.13.11.-
Reactome:R-HSA-2161775 "ALOX12 oxidises LTA4 to LXA4"
Reactome:R-HSA-2161907 "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4"
Reactome:R-HSA-2161917 "ALOX5 oxidises 15S-HpETE to LXA4/B4"
Reactome:R-HSA-5164399 "BCO2:Fe2+ cleaves betaC to APO10al and bION"
Reactome:R-HSA-9018880 "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE"
Reactome:R-HSA-9020274 "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA"
Reactome:R-HSA-9026408 "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3"
Reactome:R-HSA-9026918 "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA"
Reactome:R-HSA-9916401 "ALOX12 oxidises LTA4 to LXB4"