FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term 2-oxoglutarate-dependent dioxygenase activity ID (Ontology) GO:0016706 (Gene Ontology)
Definition Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
Also Known As "2-oxoglutarate dioxygenase activity" ; "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION      13
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 2-oxoglutarate-dependent dioxygenase activity (all annotations which use CV term, excluding "NOT" statements)       3     13
     enables | 2-oxoglutarate-dependent dioxygenase activity       --      13
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oxidoreductase activity
 |__oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__
 |__dioxygenase activity___________________________________________________________________________________|
                                                                                         2-oxoglutarate-dependent dioxygenase activity  61 rec.
                                                                                          |__2'-deoxymugineic-acid 2'-dioxygenase activity
                                                                                          |__2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
                                                                                          |__2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity
                                                                                          |__2-oxoglutarate-dependent tRNA 5-methylcytidine formyltransferase activity 1 rec.
                                                                                          |__4-coumaroyl 2'-hydroxylase activity
                                                                                          |__6-beta-hydroxyhyoscyamine epoxidase activity
                                                                                          |__[protein]-asparagine 3-dioxygenase activity
                                                                                          |__alpha-ketoglutarate-dependent xanthine dioxygenase activity
                                                                                          |__broad specificity oxidative DNA demethylase activity 1 rec.
                                                                                          |__clavaminate synthase activity
                                                                                          |__codeine O-demethylase activity
                                                                                          |__deacetoxycephalosporin-C hydroxylase activity
                                                                                          |__deoxyuridine 1'-dioxygenase activity
                                                                                          |__deoxyuridine 2'-dioxygenase activity
                                                                                          |__desacetoxyvindoline 4-hydroxylase activity
                                                                                          |__DNA 5-methylcytosine dioxygenase activity
                                                                                          |__DNA N6-methyladenine demethylase activity 2 rec.
                                                                                          |__flavanone 3-dioxygenase activity
                                                                                          |__flavone synthase activity
                                                                                          |__flavonol synthase activity
                                                                                          |__gamma-butyrobetaine dioxygenase activity 4 rec.
                                                                                          |__gibberellin 2-beta-dioxygenase activity
                                                                                          |__gibberellin 3-beta-dioxygenase activity
                                                                                          |__gibberellin 20-oxidase activity
                                                                                          |__glutarate dioxygenase activity
                                                                                          |__histone H3K4me/H3K4me2/H3K4me3 demethylase activity 3 rec.
                                                                                          |__histone H3K9me/H3K9me2 demethylase activity 1 rec.
                                                                                          |__histone H3K9me2/H3K9me3 demethylase activity 2 rec.
                                                                                          |__histone H3K27me2/H3K27me3 demethylase activity 2 rec.
                                                                                          |__histone H3K36 demethylase activity 5 rec.
                                                                                          |   |__histone H3K36me/H3K36me2 demethylase activity
                                                                                          |   |__histone H3K36me2/H3K36me3 demethylase activity 2 rec.
                                                                                          |__histone H3K56me2/H3K56me3 demethylase activity 1 rec.
                                                                                          |__histone H3R2 demethylase activity 1 rec.
                                                                                          |__histone H4K20 demethylase activity 1 rec.
                                                                                          |__histone H4R3 demethylase activity 2 rec.
                                                                                          |__hyoscyamine (6S)-dioxygenase activity
                                                                                          |__L-gamma-glutamyl-L-propargylglycine hydroxylase activity
                                                                                          |__leucocyanidin oxygenase activity
                                                                                          |__mugineic-acid 3-dioxygenase activity
                                                                                          |__oxidative RNA demethylase activity 1 rec.
                                                                                          |   |__mRNA N1-methyladenosine dioxygenase activity
                                                                                          |   |__mRNA N6-methyladenosine dioxygenase activity
                                                                                          |   |__tRNA demethylase activity
                                                                                          |__peptidyl-arginine 3-dioxygenase activity 1 rec.
                                                                                          |__peptidyl-aspartic acid 3-dioxygenase activity 1 rec.
                                                                                          |__peptidyl-histidine dioxygenase activity
                                                                                          |__peptidyl-lysine 3-dioxygenase activity 1 rec.
                                                                                          |__peptidyl-lysine 4-dioxygenase activity
                                                                                          |__peptidyl-lysine 5-dioxygenase activity 1 rec.
                                                                                          |__peptidyl-proline dioxygenase activity 29 rec.
                                                                                          |   |__peptidyl-proline 3-dioxygenase activity(+)
                                                                                          |   |__peptidyl-proline 4-dioxygenase activity(+) 27 rec.
                                                                                          |   |__procollagen-proline dioxygenase activity(+) 26 rec.
                                                                                          |__phytanoyl-CoA dioxygenase activity
                                                                                          |__procollagen-lysine 5-dioxygenase activity 1 rec.
                                                                                          |__proline 3-hydroxylase activity
                                                                                          |__sulfonate dioxygenase activity
                                                                                          |__taurine dioxygenase activity
                                                                                          |__thebaine 6-O-demethylase activity
                                                                                          |__thymine dioxygenase activity
                                                                                          |__trimethyllysine dioxygenase activity 1 rec.
                                                                                          |__tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity
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Is a oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
dioxygenase activity
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Synonyms
  • "2-oxoglutarate dioxygenase activity" EXACT
    "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
EC:1.14.11.-
Reactome:R-HSA-1234164 "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A)"
Reactome:R-HSA-6783455 "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)"