FB2026_03 , released September 17, 2026
CV Term Report
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Term oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen ID (Ontology) GO:0016712 (Gene Ontology)
Definition Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor.[ EC:1 ]
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 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (all annotations which use CV term, excluding "NOT" statements)
     enables | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
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oxidoreductase activity
 |__monooxygenase activity_________________________________________________________________________________
 |__oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen__|
                                                                                         oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  5 rec.
                                                                                          |__(+)-abscisic acid 8'-hydroxylase activity
                                                                                          |__(+)-menthofuran synthase activity
                                                                                          |__(R)-limonene 6-monooxygenase activity
                                                                                          |__(S)-limonene 3-monooxygenase activity
                                                                                          |__(S)-limonene 6-monooxygenase activity
                                                                                          |__(S)-limonene 7-monooxygenase activity
                                                                                          |__1,8-cineole 2-exo-monooxygenase activity
                                                                                          |__2,5-diketocamphane 1,2-monooxygenase activity
                                                                                          |__2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity
                                                                                          |__2-hydroxyisoflavanone synthase activity
                                                                                          |__3,5 dichloro-THPH synthase activity
                                                                                          |__3,9-dihydroxypterocarpan 6a-monooxygenase activity
                                                                                          |__3-chloro THPH synthase activity
                                                                                          |__3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity
                                                                                          |__3-hydroxyindolin-2-one monooxygenase activity
                                                                                          |__3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity
                                                                                          |__3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity
                                                                                          |__4'-methoxyisoflavone 2'-hydroxylase activity
                                                                                          |__4-hydroxyphenylacetaldehyde oxime monooxygenase activity
                                                                                          |__4-hydroxyphenylacetate 3-monooxygenase activity
                                                                                          |__5-epi-aristolochene-1,3-dihydroxylase activity
                                                                                          |__5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity
                                                                                          |__7-deoxyloganate 7-hydroxylase activity
                                                                                          |__7-deoxyloganin 7-hydroxylase activity
                                                                                          |__9beta-pimara-7,15-diene oxidase activity
                                                                                          |__11-oxo-beta-amyrin 30-oxidase activity
                                                                                          |__22alpha-hydroxysteroid 23-monooxygenase activity
                                                                                          |__24S-hydroxycholesterol 7-alpha-hydroxylase activity
                                                                                          |__25-hydroxycholesterol 7-alpha-hydroxylase activity
                                                                                          |__abieta-7,13-dien-18-ol hydroxylase activity
                                                                                          |__abieta-7,13-diene hydroxylase activity
                                                                                          |__aflatoxin B synthase activity
                                                                                          |__alkanal monooxygenase (FMN-linked) activity
                                                                                          |__alkanesulfonate monooxygenase activity
                                                                                          |__alpha-humulene 10-hydroxylase activity
                                                                                          |__alpha-tocopherol omega-hydroxylase activity
                                                                                          |__angelicin synthase activity
                                                                                          |__arachidonate omega-hydroxylase activity
                                                                                          |__aromatase activity
                                                                                          |__benzoate 4-monooxygenase activity
                                                                                          |__beta-amyrin 11-oxidase activity
                                                                                          |__beta-amyrin 16beta-monooxygenase activity
                                                                                          |__beta-amyrin 28-monooxygenase activity
                                                                                          |__brassinolide synthase activity
                                                                                          |__carotene epsilon hydroxylase activity
                                                                                          |__cholesterol 7-alpha-monooxygenase activity
                                                                                          |__cholesterol 24-hydroxylase activity
                                                                                          |__costunolide 3beta-hydroxylase activity
                                                                                          |__costunolide synthase activity
                                                                                          |__cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity
                                                                                          |__dammarenediol 12-hydroxylase activity
                                                                                          |__deoxysarpagine hydroxylase activity
                                                                                          |__dibenzothiophene monooxygenase activity
                                                                                          |__dibenzothiophene sulfone monooxygenase (NADH) activity
                                                                                          |__dihydrochelirubine 12-monooxygenase activity
                                                                                          |__dihydrosanguinarine 10-monooxygenase activity
                                                                                          |__DMNT synthase activity
                                                                                          |__ecdysteroid 25-hydroxylase activity 1 rec.
                                                                                          |__ent-cassa-12,15-diene 11-hydroxylase activity
                                                                                          |__ent-isokaurene C2-hydroxylase activity
                                                                                          |__ent-kaurene oxidase activity
                                                                                          |__ent-kaurenoic acid monooxygenase activity
                                                                                          |__estrogen 2-hydroxylase activity
                                                                                          |__estrogen 16-alpha-hydroxylase activity
                                                                                          |__farnesoate epoxidase activity 1 rec.
                                                                                          |__fatty acid omega-1 hydroxylase activity 1 rec.
                                                                                          |   |__long-chain fatty acid omega-1 hydroxylase activity
                                                                                          |   |__medium-chain fatty acid omega-1 hydroxylase activity 1 rec.
                                                                                          |__fatty acid omega-hydroxylase activity
                                                                                          |   |__long-chain fatty acid omega-hydroxylase activity
                                                                                          |   |__medium-chain fatty acid omega-hydroxylase activity
                                                                                          |   |__very long-chain fatty acid omega-hydroxylase activity
                                                                                          |__flavanone 2-hydroxylase activity
                                                                                          |__flavonoid 3',5'-hydroxylase activity
                                                                                          |__flavonoid 3'-monooxygenase activity
                                                                                          |__fraxetin 5-hydroxylase activity
                                                                                          |__geraniol 10-hydroxylase activity
                                                                                          |__germacrene A acid 8beta-hydroxylase activity
                                                                                          |__germacrene A hydroxylase activity
                                                                                          |__glyceollin synthase activity
                                                                                          |__heme oxygenase (decyclizing) activity 1 rec.
                                                                                          |__homomethionine N-monooxygenase activity
                                                                                          |__indole-2-monooxygenase activity
                                                                                          |__indole-3-carbonyl nitrile 4-hydroxylase activity
                                                                                          |__indolin-2-one monooxygenase activity
                                                                                          |__isoflavone 2'-hydroxylase activity
                                                                                          |__isoflavone 3'-hydroxylase activity
                                                                                          |__isoleucine N-monooxygenase (oxime forming) activity
                                                                                          |__L-phenylalanine N-monooxygenase activity
                                                                                          |__labd-13Z-ene-9,15,16-triol synthase activity
                                                                                          |__leukotriene-B4 20-monooxygenase activity
                                                                                          |__linalool 8-monooxygenase activity
                                                                                          |__lithocholate 6beta-hydroxylase activity
                                                                                          |__methyl farnesoate epoxidase activity 1 rec.
                                                                                          |__methyltetrahydroprotoberberine 14-monooxygenase activity
                                                                                          |__N-methylcoclaurine 3'-monooxygenase activity
                                                                                          |__naringenin 2-hydroxylase activity
                                                                                          |__nitrilotriacetate monooxygenase activity
                                                                                          |__parthenolide 3beta-hydroxylase activity
                                                                                          |__parthenolide synthase activity
                                                                                          |__phenylacetate 2-hydroxylase activity
                                                                                          |__pipecolic acid N-hydroxylase activity
                                                                                          |__protopanaxadiol 6-hydroxylase activity
                                                                                          |__protopine 6-monooxygenase activity
                                                                                          |__psoralen synthase (NADPH) activity
                                                                                          |__quinine 3-monooxygenase activity
                                                                                          |__squalene monooxygenase activity
                                                                                          |__steroid 17-alpha-monooxygenase activity
                                                                                          |   |__androst-4-ene-3,17-dione monooxygenase activity
                                                                                          |__steroid 21-monooxygenase activity
                                                                                          |   |__17-hydroxyprogesterone 21-hydroxylase activity
                                                                                          |   |__progesterone 21-hydroxylase activity
                                                                                          |__steroid 22S-hydroxylase activity
                                                                                          |__sterol 12-alpha-hydroxylase activity
                                                                                          |__sterol 14-demethylase activity
                                                                                          |__tabersonine 16-hydroxylase activity
                                                                                          |__taurochenodeoxycholate 6alpha-hydroxylase activity
                                                                                          |__taxane 10-beta-hydroxylase activity
                                                                                          |__taxane 13-alpha-hydroxylase activity
                                                                                          |__taxoid 2alpha-hydroxylase activity
                                                                                          |__taxoid 7beta-hydroxylase activity
                                                                                          |__testosterone 16-alpha-hydroxylase activity
                                                                                          |__thalianol hydroxylase activity
                                                                                          |__trans-cinnamate 4-monooxygenase activity
                                                                                          |__tryptophan N-monooxygenase activity
                                                                                          |__tyrosine N-monooxygenase activity
                                                                                          |__valine N-monooxygenase (oxime forming) activity
                                                                                          |__vinorine hydroxylase activity
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Is a monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Part of
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Synonyms
  • "aryl hydrocarbon hydroxylase activity" NARROW[ EC:1 ]
    "aryl-4-monooxygenase activity" NARROW[ EC:1 ]
    "cytochrome p450 activity" NARROW[ EC:1 ]
    "cytochrome P450 CYP19" NARROW
    "flavoprotein monooxygenase activity" NARROW[ EC:1 ]
    "flavoprotein-linked monooxygenase activity" NARROW[ EC:1 ]
    "microsomal monooxygenase activity" NARROW[ EC:1 ]
    "microsomal P-450" NARROW[ EC:1 ]
    "microsomal p450 activity" NARROW[ EC:1 ]
    "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)" RELATED[ EC:1 ]
    "unspecific monooxygenase activity" NARROW
    "xenobiotic monooxygenase activity" NARROW[ EC:1 ]
Secondary IDs
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EC:1.14.14.-
EC:1.14.14.1
MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN
Reactome:R-HSA-194678 "CYP51A1 demethylates LAN"
Reactome:R-HSA-211966 "CYP2D6 4-hydroxylates debrisoquine"
RHEA:17149
RHEA:51984
RHEA:68160
RHEA:75847
RHEA:75863
RHEA:76419